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NCT07056842
This is an Open-label, Non-randomized Study to Assess the Pharmacokinetics (PK) of VCT220 in Healthy Volunteers When Administered With Rifampin or Itraconazole
Phase 1 trial testing Rifampin + VCT220 in Obesity &Amp; Overweight in 32 participants. Completed in 30 September 2025.
11 August 2025
Quick facts
| Lead sponsor | Vincentage Pharma Co., Ltd |
|---|---|
| Phase | Phase 1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | sequential |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 32 |
| Start date | 20 July 2025 |
| Primary completion | 11 August 2025 |
| Estimated completion | 30 September 2025 |
| Sites | 1 location across China |
Drugs / interventions tested
- Rifampin + VCT220 — full drug profile →
- Itraconazole + VCT220 — full drug profile →
Conditions studied
- Obesity &Amp; Overweight — all drugs for Obesity &Amp; Overweight →
Sponsor
Vincentage Pharma Co., Ltd — full company profile →
Who can join
Adults 18 to 50, any sex, with Obesity &Amp; Overweight. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This is a single-center, open-label, single-arm, fixed-sequence Phase I study in healthy participants to evaluate the effect of multiple doses of rifampin or itraconazole on the pharmacokinetics (PK) of VCT220 and its metabolite VCT289. Cohort 1 will assess the impact of rifampin (600 mg once daily) on VCT220 (160 mg single dose). Cohort 2 will assess the impact of itraconazole (200 mg once daily) on VCT220 (40 mg single dose). A total of 32 healthy subjects will be enrolled, 16 in each cohort.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07056842
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Vincentage Pharma Co., Ltd trials
Trials by the same sponsor.
- NCT07349381 — A Food-Effect Study of CX11 in Healthy Participants · Phase 1 · recruiting
- NCT07360275 — A Study of VCT220 in Participants With Hypertension and Obesity or Overweight · Phase 2 · not yet recruiting
- NCT07347808 — A Pharmacokinetic Study of VCT220 With Moderate Renal Impairment Patients · Phase 1 · completed
- NCT07065058 — A Drug Drug Interaction Study to Evaluate the Effect of VCT220 on the Pharmacokinetics of Repaglinide, Rosuvastatin, and · Phase 1 · completed
- NCT06938529 — A Pharmacokinetic Study of VCT220 in Particicants With Hepatic Injury and Normal Hepatic Function · Phase 1 · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07056842 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Vincentage Pharma Co., Ltd
- Last refreshed: 31 March 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07056842.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing