NCT07056075: PrePAP-ERCP

Prevention of Desaturations Using Positive Airway Pressure or Capnometry During ERCP

Recruiting now NA Last updated 24 March 2026

What this trial tests

NA trial testing Nasal PAP Ventilation System in Desaturation in 288 participants. Currently enrolling.

Timeline

7 July 2025

Primary endpoint
30 November 2026

30 December 2026

Quick facts

Lead sponsor	Karl Landsteiner University of Health Sciences
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	prevention
Enrollment	288
Start date	7 July 2025
Primary completion	30 November 2026
Estimated completion	30 December 2026
Sites	2 locations across Austria

Drugs / interventions tested

• Nasal PAP Ventilation System
• Low Flow Oxygen — full drug profile →
• Capnometry

Conditions studied

• Desaturation — all drugs for Desaturation →
• Hypoxemia — all drugs for Hypoxemia →
• ERCP — all drugs for ERCP →

Sponsor

Karl Landsteiner University of Health Sciences

Who can join

Adults 18 to 99, any sex, with Desaturation or Hypoxemia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Although sedation during endoscopy is sufficiently safe, desaturations are among the most common side effects of endoscopic retrograde cholangiopancreatography (ERCP) procedures, occurring in approximately 20-30% of cases. Sedation during endoscopy increases the complication rate, and a significant proportion of severe and serious side effects are respiratory/airway-related. However, most patients require sedation to complete the procedure and achieve adequate outcomes during therapeutic ERCP. Therefore, improved measures to increase ERCP safety are needed. Since the demand for anesthesia in many centers already (far) exceeds current capacities, performing additional ERCPs under general anesthesia is not an option. Innovative ways to improve cardiorespiratory monitoring or respiratory management during ERCP could offer a solution without significantly increasing costs. Fortunately, dedicated devices for respiratory management and/or monitoring during endoscopy already exist, but their impact on improving patient safety has not yet been well studied. Therefore, the aim of this prospective, randomized, open-label, non-interventional study is to investigate the effects of non-invasive airway management and respiratory monitoring devices on desaturation rate during endoscopic retrograde cholangiopancreatography.

For this purpose, 288 adult patients (male and female, 18+ years) undergoing ERCP for medical reasons will be enrolled and randomized to one of three groups: (i) airway management using positive airway pressure (PAP group), (ii) additional monitoring using capnography (capnography group), and (iii) a control group with standard monitoring/treatment (i.e., 2 L O2/min via nasal cannula) (control group). Patients are monitored during the ERCP procedure according to medical standards (non-invasive blood oxygen saturation measurement = SpO2, regular non-invasive blood pressure measurement, pulse), and all desaturation events (defined as an SpO2 \<85% for any duration according to guidelines) are recorded and treated according to guideline recommendations (the studies do not specify any measures for the (non-)treatment of desaturations). After the procedure, patients are followed (passively) for 30 days (review of medical records) to record late complications. The main outcome parameter is the comparison of the desaturation rate in the PAP versus the control group.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.