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NCT07046117: Tezebarrier
Effect of Tezepelumab on Barrier Function in Severe Asthmatic Patients With and Without Comorbid Chronic Rhinosinusitis With Nasal Polyps
NA trial testing Tezepelumab in Asthma Bronchiale in 20 participants. Not yet recruiting.
31 January 2028
Quick facts
| Lead sponsor | Medical University of Vienna |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | single group |
| Masking | none |
| Primary purpose | basic science |
| Enrollment | 20 |
| Start date | 1 October 2025 |
| Primary completion | 31 January 2028 |
| Estimated completion | 1 August 2028 |
| Sites | 1 location across Austria |
Drugs / interventions tested
- Tezepelumab (TEZEPELUMAB) — full drug profile →
Conditions studied
- Asthma Bronchiale — all drugs for Asthma Bronchiale →
- Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) — all drugs for Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) →
Sponsor
Medical University of Vienna
Who can join
Adults 18 to 99, any sex, with Asthma Bronchiale or Chronic Rhinosinusitis With Nasal Polyps (CRSwNP). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In this study, we will investigate the effect of tezepelumab on the epithelial barrier function of the upper and lower airways in patients suffering from severe asthma with and without chronic rhinosinusitis with nasal polyps. This will be achieved by analysis of epithelial barrier function upon challenge with various harmful substances (e.g. cigarette smoke extract, allergens) in cultured primary respiratory tract epithelial cells. Furthermore we will assess changes in clinical parameters, cellular composition and inflammatory mediators.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07046117
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Trials testing the same drug.
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Other recruiting trials for Asthma Bronchiale
Currently open trials in the same condition.
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- NCT06966271 — Investigation of the Respiratory Profile of Patients With Obstructive Pulmonary Disease (ASTHMA, COPD) · recruiting
- NCT06636487 — Expand Pulmonary Rehabilitation to Other Chronic Respiratory Diseases Than COPD · NA · active not recruiting
- NCT06678191 — Investigation of Fixed Triple Inhaled Combination in Asthmatic Patients, in a Real-life Setting · recruiting
- NCT06842836 — Evaluation of Alterations in the Gut Microbiota in Pediatric Bronchial Asthma · active not recruiting
Other Medical University of Vienna trials
Trials by the same sponsor.
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- NCT07516990 — Intramuscular Injection of Mashed Parathyroid Tissue Into a Forearm During Thyroid Surgery to Prevent Permanent Postoper · NA · recruiting
- NCT07496437 — Is Cross-linked Hyaluronic Acid a Biologic Alternative for Alveolar Ridge Preservation? · NA · not yet recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07046117 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Medical University of Vienna
- Last refreshed: 1 July 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07046117.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing