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NCT07045818
DLPFC and Sympathetic Reactivity in RPL With Anxiety
trial testing Emotional provocation task involving multisensory aversive stimuli in Recurrent Pregnancy Loss Without Current Pregnancy in 50 participants. Currently enrolling.
30 March 2026
Quick facts
| Lead sponsor | Shenyang Medical College |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 50 |
| Start date | 1 July 2025 |
| Primary completion | 30 March 2026 |
| Estimated completion | 31 March 2026 |
| Sites | 2 locations across China |
Drugs / interventions tested
- Emotional provocation task involving multisensory aversive stimuli
Conditions studied
- Recurrent Pregnancy Loss Without Current Pregnancy — all drugs for Recurrent Pregnancy Loss Without Current Pregnancy →
- Anxiety Disorder — all drugs for Anxiety Disorder →
Sponsor
Shenyang Medical College
Who can join
Adults 18 to 45, female only, with Recurrent Pregnancy Loss Without Current Pregnancy or Anxiety Disorder. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
We propose an exploratory clinical study (NEURO-CARD-2) that employs simultaneous functional near-infrared spectroscopy (fNIRS) and electrocardiography (ECG) to investigate interhemispheric dysfunction in the dorsolateral prefrontal cortex (DLPFC) and its relationship with autonomic sympathetic activation in women with recurrent pregnancy loss (RPL) and comorbid anxiety. Using a standardized multisensory aversive emotional stimulation paradigm, the study will assess cortical and cardiac responses within the framework of the Brain-Heart-Emotion interaction model. The objective is to identify neurobiological signatures underlying emotion-autonomic dysregulation in this population, thereby informing future development of precision-targeted interventions.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07045818
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Related trials
Other Shenyang Medical College trials
Trials by the same sponsor.
- NCT07325370 — Cardiac Autonomic and Anxiety Regulation Via Closed-loop nEurofeedback in Recurrent Pregnancy Loss · NA · not yet recruiting
- NCT07244484 — Closed-Loop Neurofeedback Targeting the Left Dorsolateral Prefrontal Cortex for Cardiac Autonomic Modulation in Coronary · NA · not yet recruiting
- NCT07233278 — High-Intensity, Low-Frequency Periodic rTMS Over the Right Dorsolateral Prefrontal Cortex on Cardiac Autonomic Regulatio · NA · not yet recruiting
- NCT07238920 — Closed-Loop Neurofeedback Targeting the Right Dorsolateral Prefrontal Cortex for Cardiac Autonomic Modulation in Coronar · NA · not yet recruiting
- NCT07198061 — Efficacy and Safety of Cold Atmospheric Plasma Combined With Endovascular Intervention for Diabetic Foot Ulcers With Low · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07045818 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Shenyang Medical College
- Last refreshed: 18 November 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07045818.
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