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NCT07038161: POPF
The Novel Modified Cattell-Warren Duct-To-Mucosa Pancreaticojejunostomy Technique Significantly Reduces POPF.
trial testing Modified Cattell-Warren duct-to-mucosa pancreaticojejunostomy in Pancreaticoduodenectomy in 27 participants. Completed in 9 June 2025.
4 June 2025
Quick facts
| Lead sponsor | Nepal Medical College and Teaching Hospital |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 27 |
| Start date | 1 April 2023 |
| Primary completion | 4 June 2025 |
| Estimated completion | 9 June 2025 |
| Sites | 1 location across Nepal |
Drugs / interventions tested
- Modified Cattell-Warren duct-to-mucosa pancreaticojejunostomy
- Institutional Prehabilitation Protocol
Conditions studied
- Pancreaticoduodenectomy — all drugs for Pancreaticoduodenectomy →
- Distal Pancreatectomy — all drugs for Distal Pancreatectomy →
- Postoperative Pancreatic Fistula — all drugs for Postoperative Pancreatic Fistula →
Sponsor
Nepal Medical College and Teaching Hospital
Who can join
18 and older, any sex, with Pancreaticoduodenectomy or Distal Pancreatectomy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Pancreatic surgeries, such as pancreaticoduodenectomy and distal pancreatectomy, are associated with high morbidity and mortality. The most common cause of this morbidity is postoperative pancreatic fistula(POPF). The risk of POPF depends on the texture of pancreatic parenchyma, the size of the main pancreatic duct, and the technique of pancreatic-enteric reconstruction. There are several techniques for pancreaticojejunostomy anastomosis. Among which duct to mucosa is considered a relatively safe anastomosis technique. However, there are several modifications to the duct-to-mucosa technique. The investigators of this study believe that the modified Cattell-Warren duct-to-mucosa technique, which includes taking more than 5 mm of periductal pancreatic parenchyma with the duct and the full-thickness jejunum while performing pancreaticojejunostomy reconstruction with proper perioperative nutritional optimization and prehabilitation, improves patient outcomes. So the investigators aim to assess the risk of POPF in the novel modified Cattell-Warren technique.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07038161
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Currently open trials in the same condition.
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- NCT07412301 — The Effect of Celiac Axis Stenosis on Morbidity After Pancreatoduodenectomy - A Prospective Study · active not recruiting
- NCT06322680 — Impact of External Drainage of the Main Pancreatic Duct and Common Bile Duct on Pancreatic Fistula Following Pancreatico · NA · recruiting
- NCT03785743 — Comparing Laparoscopic and Open Surgery for Pancreatic Carcinoma · NA · recruiting
Other Nepal Medical College and Teaching Hospital trials
Trials by the same sponsor.
- NCT05767827 — Effect of Dexmedetomidine As Adjuvant to Ropivacaine for Brachial Plexus Block · NA · completed
- NCT06573632 — Perioperative TPN Improves Surgical Outcomes · completed
- NCT07530874 — Ultrasonography vs Intraoperative Laparoscopic Cholecystectomy for Gall Stone Disease · completed
- NCT04675190 — Major Surgery as a Risk of Gall Stone Disease? · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07038161 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Nepal Medical College and Teaching Hospital
- Last refreshed: 26 June 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07038161.
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