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NCT07033351
The Effect of Platelet Rich Fibrin Layers on Peri-implant Tissue Phenotype
NA trial testing Dental implant placement without PRF in Dental Implant in 31 participants. Completed in 6 June 2025.
6 June 2025
Quick facts
| Lead sponsor | Al-Mustansiriyah University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 31 |
| Start date | 1 February 2025 |
| Primary completion | 6 June 2025 |
| Estimated completion | 6 June 2025 |
| Sites | 1 location across Iraq |
Drugs / interventions tested
- Dental implant placement without PRF
- Single-layer PRF membrane application — full drug profile →
- Triple-layer PRF membrane application — full drug profile →
Conditions studied
- Dental Implant — all drugs for Dental Implant →
- Platelet Rich Fibrin — all drugs for Platelet Rich Fibrin →
- Keratinized Mucosa — all drugs for Keratinized Mucosa →
- Crestal Bone Loss — all drugs for Crestal Bone Loss →
Sponsor
Al-Mustansiriyah University
Who can join
Adults 18 to 75, any sex, with Dental Implant or Platelet Rich Fibrin. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The present investigation seeks to determine how varying quantities of Platelet-Rich Fibrin (PRF) membranes influence the repair of both gingival and osseous tissues adjacent to dental implants. A secondary objective is to establish whether the incorporation of PRF contributes to enhanced stability of the soft-tissue cover and more effective retention of alveolar bone over an extended period. Central to the study are two specific inquiries: Does the application of PRF correlate with an increase in the width and thickness of keratinized mucosa surrounding the implant? Is there a dose-response relationship such that the use of multiple PRF layers yields superior maintenance of bone height compared with a single layer or no PRF at all? To address these questions, clinicians will juxtapose three treatment groups: one receiving no PRF, another receiving a single membrane, and a third receiving a triple-layer graft. Healing parameters will be measured before surgery and again at 6-week and 12-week checkpoints, allowing direct appraisal of outcome changes across the comparative cohorts. Each participant will ultimately be allotted to one of the experimental arms by random assignment, thus mitigating selection bias. Routine follow-up examinations and radiographic imaging, will be used to track healing progress.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07033351
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Al-Mustansiriyah University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07033351 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Al-Mustansiriyah University
- Last refreshed: 27 June 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07033351.
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