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Long-term Immunogenicity of L-HAV Vaccine Among Healthy Thai Children and Adolescents
Hepatitis A virus (HAV) remains a common infection among Thai children. Two types of HAV vaccines are available in Thailand: an inactivated vaccine (I-HAV, administered in two doses 6 months apart) and a live-attenuated vaccine (L-HAV, administered as a single dose). However, neither vaccine is currently included in Thailand's Expanded Programme on Immunization (EPI). In 2024, a randomized, active-controlled, open-label, non-inferiority trial was conducted to compare the immunogenicity and safety of the two-dose I-HAV with the single-dose L-HAV in healthy Thai children and adolescents aged 18 months to 18 years. This study aims to evaluate the long-term seropositive rate and immunogenicity of anti-HAV antibodies in this population following a single dose of L-HAV.
Details
| Lead sponsor | Chiang Mai University |
|---|---|
| Status | NOT_YET_RECRUITING |
| Enrolment | 60 |
| Start date | Sun Jun 22 2025 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Tue Sep 30 2025 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Hepatitis A
- Hepatitis A Virus
- Vaccine-Preventable Diseases
Countries
Thailand