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NCT07017374
Proteomic Analysis of Serum Samples After Cardiac Arrest: a TTM-trial Substudy
trial testing Proteomic analysis, targeted temperature management in Cardiac Arrest (CA) in 682 participants. Participants enrolled and being followed up; not accepting new ones.
31 December 2025
Quick facts
| Lead sponsor | Region Skane |
|---|---|
| Status | Active, enrolled |
| Study type | OBSERVATIONAL |
| Enrollment | 682 |
| Start date | 22 May 2025 |
| Primary completion | 31 December 2025 |
| Estimated completion | 31 December 2025 |
| Sites | 1 location across Sweden |
Drugs / interventions tested
- Proteomic analysis, targeted temperature management
Conditions studied
- Cardiac Arrest (CA) — all drugs for Cardiac Arrest (CA) →
- Proteomics — all drugs for Proteomics →
Sponsor
Region Skane — full company profile →
Who can join
18 and older, any sex, with Cardiac Arrest (CA) or Proteomics. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Cardiac arrest remains a large contributor to morbidity and mortality. Animal studies suggest an improvement in mortality and neurological function with hypothermia after cardiac arrest, a finding that could not be verified in large clinical trials such as Target Temperature Management after Out-of-hospital Cardiac arrest (TTM) trial. Multimodal neuroprognostication is an important tool for differentiating patients that will recover after cardiac arrest, and currently only one biomarker is in clinical use. The purpose of this study is to explore proteomics profiles in TTM trial patients in order to search for potential novel biomarkers, therapeutic targets, and to explore phenotypes of post-cardiac arrest syndrome.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Proteomic analysis of serum samples after cardiac arrest: Rationale and design of a TTM-trial substudy.
Lileikyte G, Bakochi A, Isaksson M, Årman F, et al · · 2025 · PMID 40688254 · DOI 10.1016/j.resplu.2025.101014
Verify or expand the search:
- PubMed search for NCT07017374
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Region Skane trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07017374 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Region Skane
- Last refreshed: 12 June 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07017374.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing