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Effect of Super-Oxygenated Water on Blood Oxygen Saturation
NA trial testing Ingestion of Water in Adult Subject in 60 participants. Completed in 28 November 2025.
| Lead sponsor | Inhale, Inc |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | other |
| Enrollment | 60 |
| Start date | 1 May 2025 |
| Primary completion | 26 November 2025 |
| Estimated completion | 28 November 2025 |
| Sites | 1 location across United States |
Inhale, Inc
18 and older, any sex, with Adult Subject. Patients with the condition only — healthy volunteers not accepted.
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Number of participants who experienced an improvement in post-ingestion SpO2. An increase in post-ingestion SpO2 over the pre-ingestion level in the same subject was considered a response.
| Group | Value | 95% CI |
|---|---|---|
| Inhale Super-Oxygenated Water | 21 | ± 0.5404 |
| Placebo Control | 11 | ± 0.3117 |
Number of participants who experienced a reduction in post-ingestion heart rate. A decrease in post-ingestion heart rate over the pre-ingestion level in the same subject was considered a response.
| Group | Value | 95% CI |
|---|---|---|
| Inhale Super-Oxygenated Water | 21 | ± 2.603 |
| Placebo Control | 14 | ± 1.347 |
Number of participants who reported an improvement in post-ingestion energy level. An increase in post-ingestion energy level over the pre-ingestion level in the same subject was considered a response. Energy level was measured by a participant-reported questionnaire titled "Energy Level and Brain Clarity Assessment" with possible scores ranging from 1 (meaning "very-low") through 10 (meaning "very-high") where higher score indicated a greater energy level.
| Group | Value | 95% CI |
|---|---|---|
| Inhale Super-Oxygenated Water | 17 | ± 7.520 |
| Placebo Control | 6 | ± 3.278 |
Number of participants who reported an improvement in post-ingestion brain clarity. An increase in post-ingestion brain clarity over the pre-ingestion level in the same subject was considered a response. Brain clarity was measured by a participant-reported questionnaire titled "Energy Level and Brain Clarity Assessment" with possible scores ranging from 1 (meaning "very-low") through 10 (meaning "very-high") where higher score indicated a greater brain clarity.
| Group | Value | 95% CI |
|---|---|---|
| Inhale Super-Oxygenated Water | 15 | ± 3.827 |
| Placebo Control | 5 | ± 3.519 |
Therapeutic delivery of additional Oxygen to blood stream via hyperbaric and extracorporeal oxygenation that raises blood Oxygen saturation level, apart from oxygenation in the lungs, is known to induce tissue repair, restore normal body functions and improve survival. Despite the clinical benefits obtained from these interventions, Oxygen supplementation is rather a medically involved process requiring access to specialized equipment including hyperbaric chambers, cardiac catheterization laboratory and extracorporeal oxygenators, and is not generally amenable for everyday use. The current prospective study will evaluate a non-invasive route for Oxygen delivery through ingestion of super-oxygenated water in adult volunteers. The participants will be randomly assigned to one of the two study groups viz. Inhale super-oxygenated water or placebo control normal water at 1:1 ratio. Neither the participants nor the study doctor will know the treatment assignment. Pre- and post-ingestion measurements will be conducted to evaluate effect of super-oxygenated water.
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
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