NCT07009119: LPD

Laparoscopic Pancreaticoduodenectomy

Recruiting now NA Last updated 29 August 2025

What this trial tests

NA trial testing laparoscopic Pancreaticoduodenectomy in Pancreatic Cancer in 30 participants. Currently enrolling.

Timeline

1 June 2025

Primary endpoint
1 June 2026

1 July 2026

Quick facts

Lead sponsor	Minia University
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	30
Start date	1 June 2025
Primary completion	1 June 2026
Estimated completion	1 July 2026
Sites	1 location across Egypt

Drugs / interventions tested

• laparoscopic Pancreaticoduodenectomy

Conditions studied

• Pancreatic Cancer — all drugs for Pancreatic Cancer →
• Pancreatic Fistula — all drugs for Pancreatic Fistula →
• Periampullary Cancer — all drugs for Periampullary Cancer →

Sponsor

Minia University

Who can join

Adults 18 to 75, any sex, with Pancreatic Cancer or Pancreatic Fistula. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Laparoscopic pancreaticoduodenectomy was first performed by Garner and Pomp in 1994. This is a technically difficult, time consuming and high rate of complication procedure. The reason is that duodenum and head of pancreas locate deeply in retroperitoneum and are surrounded by important structures such as inferior vena cava, abdominal aorta, superior mesenteric artery, superior mesenteric vein (SMV), portal vein (PV) and hepatic arteries. Injuring these structures during the surgery can lead to life-threatening complications. Moreover, doing anastomoses through laparoscopy, especially pancreatic anastomosis, is more difficult and takes more time than through open approach. The outcome of PD has improved over the last two decades due to advances in surgical techniques, anesthesia and perioperative care. Although studies from high volume centers demonstrate reduce in the operative mortality to less than 3%, the postoperative morbidity rate is still ranging from 30% to 60%. Laparoscopic surgery is being used increasingly as a less invasive alternative to traditional interventions for pancreatic resection. Laparoscopic pancreaticoduodenectomy (LPD) is a difficult procedure that has become increasingly popular. Nevertheless, comparative data on outcomes remain limited. In this prospective study, investigators evaluate the safety and feasibility of surgical and oncological outcomes of minimally invasive PD.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.