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NCT07008443
An Integrated Artificial Intelligence Approach for Predicting Analgesic Time Based on Nalbuphine Versus Morphine as Adjuvants to Bupivacaine in Ultrasound-Guided Supraclavicular Block
Phase 4 trial testing Bupivacaine + saline in Regional Anesthesia Block in 60 participants. Completed in 1 April 2025.
1 April 2025
Quick facts
| Lead sponsor | Alzahraa Ahmed Abbas |
|---|---|
| Phase | Phase 4 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 60 |
| Start date | 1 January 2024 |
| Primary completion | 1 April 2025 |
| Estimated completion | 1 April 2025 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- Bupivacaine + saline — full drug profile →
- Bupivacaine + nalbuphine — full drug profile →
- Bupivacaine + morphine — full drug profile →
Conditions studied
- Regional Anesthesia Block — all drugs for Regional Anesthesia Block →
- Upper Limb Surgery — all drugs for Upper Limb Surgery →
Sponsor
Alzahraa Ahmed Abbas — full company profile →
Who can join
Adults 21 to 60, any sex, with Regional Anesthesia Block or Upper Limb Surgery. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study investigated the effect of adding nalbuphine or morphine to bupivacaine for supraclavicular brachial plexus block in upper limb surgeries. Sixty adult patients were randomized into three groups: control (bupivacaine + saline), nalbuphine, and morphine. The primary objective was to compare the duration of analgesia between the groups. A secondary goal was to assess whether artificial intelligence (AI), specifically the k-nearest neighbor (KNN) algorithm, could predict analgesic duration based on patient clinical and demographic data. The study concluded that both nalbuphine and morphine significantly prolonged analgesic duration and that the AI model showed high predictive accuracy.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Effect of nalbuphine and morphine as adjuvants to bupivacaine in ultrasound-guided supraclavicular block: a randomized controlled trial with machine learning-based predictive analysis.
Abbas AA, Ghoneim S, Sharf M, Farag A. · · 2025 · PMID 41455918 · DOI 10.1186/s12871-025-03537-6
Verify or expand the search:
- PubMed search for NCT07008443
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Bupivacaine + saline
Trials testing the same drug.
- NCT06747975 — Preventative Effect of Combining Dexamethasone with Ondansetron on Postoperative Nausea, Vomiting and Shivering in Child · Phase 4 · not yet recruiting
Other recruiting trials for Regional Anesthesia Block
Currently open trials in the same condition.
- NCT07062497 — Clonidine in Ultrasound-guided Rectus Sheath Block for Outpatient Umbilical Hernioplasty · Phase 2, PHASE3 · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07008443 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Alzahraa Ahmed Abbas
- Last refreshed: 6 June 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07008443.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing