Last reviewed · How we verify
A Cohort Study on Treating Primary Nocturnal Enuresis by Regulating Central-Peripheral Circadian Rhythm
Primary nocturnal enuresis (PNE), a prevalent pediatric disorder, suffers from therapeutic limitations characterized by low efficacy and high relapse rates. Targeting its core pathophysiology could significantly improve treatment outcomes. Growing evidence implicates circadian dysregulation in PNE pathogenesis. Our preliminary fMRI cohort identified abnormal functional connectivity between the suprachiasmatic nucleus (SCN, the central circadian pacemaker) and superior temporal gyrus in PNE patients, with clinical data confirming circadian realignment correlates with symptom remission. Small-scale pilot studies and clinical observations indicate that modulating central and peripheral circadian rhythms significantly alleviates PNE symptoms. This study will establish a circadian-focused PNE cohort to quantify therapeutic efficacy and elucidate underlying mechanisms, ultimately driving the development of mechanism-based therapies for PNE.
Details
| Lead sponsor | Shanghai Children's Medical Center |
|---|---|
| Phase | NA |
| Status | NOT_YET_RECRUITING |
| Enrolment | 200 |
| Start date | Tue Jul 01 2025 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Thu Jun 01 2028 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Primary Nocturnal Enuresis
Interventions
- Circadian Rhythm Intervention Combined with Bladder Training
- Bladder Training (basic treatment for enuresis)
Countries
China