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NCT06999772
Combining Brain Stimulation and Physiotherapy for the Management of Chronic Low Back Pain
NA trial testing Active rTMS in Chronic Low-back Pain (cLBP) in 96 participants. Currently enrolling.
1 November 2026
Quick facts
| Lead sponsor | Laval University |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 96 |
| Start date | 11 June 2025 |
| Primary completion | 1 November 2026 |
| Estimated completion | 1 June 2027 |
| Sites | 2 locations across Canada |
Drugs / interventions tested
- Active rTMS
- Sham rTMS
- Psychologically-informed physiotherapy (PiP)
- Usual physiotherapy
Conditions studied
- Chronic Low-back Pain (cLBP) — all drugs for Chronic Low-back Pain (cLBP) →
Sponsor
Laval University
Who can join
Adults 18 to 65, any sex, with Chronic Low-back Pain (cLBP). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Chronic low back pain (CLBP) is a major health challenge in Canada, leading to substantial disability and socioeconomic burden, particularly among Veterans. In military Veterans, LBP is the most common chronic pain condition. Conventional interventions have limited effectiveness. The refractoriness to interventions suggests that specific CLBP mechanisms may be missed by current treatments, prompting a shift towards psychologically informed approaches which aim to address emotional and cognitive factors alongside biomedical aspects. The integration of these concepts into physiotherapy is called psychologically informed physiotherapy (PiP). Despite promising results of PiP from randomized controlled trials, residual pain and disability often persist in Veterans. Non-invasive brain stimulation, such as repetitive transcranial magnetic stimulation (rTMS), may enhance the effectiveness of PiP by modulating cognition, emotion, and pain. This proposal seeks to determine whether non-invasive brain stimulation can enhance the effects of PiP.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Combining Noninvasive Brain Stimulation and Physiotherapy to Improve the Management of Chronic Low Back Pain in Veterans: Protocol for a Multi-Arm Randomized Controlled Trial.
Dupuis F, Tousignant-Laflamme Y, Marier Deschênes P, Fournier P, et al · · 2026 · PMID 41587077 · DOI 10.2196/78952
Verify or expand the search:
- PubMed search for NCT06999772
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Trials testing the same drug.
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- NCT06670820 — iTBS in MCI and Mild AD · NA · not yet recruiting
Other recruiting trials for Chronic Low-back Pain (cLBP)
Currently open trials in the same condition.
- NCT07388134 — Virtual Reality Based High-intensity Interval Training in Chronic Low Back Pain · NA · active not recruiting
- NCT07334782 — Effects of Vertebral Axial Loading Walking Combined With Core Stabilization Exercises in Individuals With Chronic Low Ba · NA · active not recruiting
- NCT07280806 — Biopsychosocial Model-based Care Versus Routine Physical Therapy in Chronic Back Pain · NA · recruiting
- NCT07133139 — Treatment Validation for Myofascial Pain · NA · recruiting
- NCT07211464 — Acceptance and Commitment Therapy Plus Exercise for Older People With Chronic Low-back Pain: A Pragmatic Cluster Randomi · NA · recruiting
Other Laval University trials
Trials by the same sponsor.
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- NCT07366827 — Effectiveness of Motorised Lumbar Support for Non-specific Low Back Pain · NA · not yet recruiting
- NCT07317973 — A Study About Patient Decision Aids Designed to Help Parents and Guardians in Canada Make Evidence-informed, Values-cong · NA · not yet recruiting
- NCT07293312 — Optimizing the Use of Virtual Reality in Rehabilitation for Individuals With Persistent Shoulder Pain · NA · not yet recruiting
- NCT07201870 — Digital Preparation for Bariatric Surgery: Feasability Pilot Trial · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06999772 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Laval University
- Last refreshed: 20 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06999772.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing