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NCT06992141: CHIVAS-M1
A Strep Throat Controlled Human Infection Trial in Healthy Adults
EARLY_PHASE1 trial testing Streptococcus pyogenes M1UK strain MCRI0102 in Streptococcus Pyogenes Pharyngitis in 40 participants. Completed in 16 February 2026.
31 October 2025
Quick facts
| Lead sponsor | Murdoch Childrens Research Institute |
|---|---|
| Phase | EARLY_PHASE1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | basic science |
| Enrollment | 40 |
| Start date | 24 July 2025 |
| Primary completion | 31 October 2025 |
| Estimated completion | 16 February 2026 |
| Sites | 1 location across Australia |
Drugs / interventions tested
- Streptococcus pyogenes M1UK strain MCRI0102 — full drug profile →
Conditions studied
- Streptococcus Pyogenes Pharyngitis — all drugs for Streptococcus Pyogenes Pharyngitis →
- Streptococcus Infection — all drugs for Streptococcus Infection →
Sponsor
Murdoch Childrens Research Institute
Who can join
Adults 18 to 40, any sex, with Streptococcus Pyogenes Pharyngitis or Streptococcus Infection. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This aim of this study is to further develop a new way to study the bacteria that causes pharyngitis (strep throat). The scientific name for this bacterium is Streptococcus pyogenes and it is commonly known as Strep A. Strep A is a common type of bacteria that can cause various infections. These range from skin infections and strep throat to more serious conditions like rheumatic heart disease. In recent years there has been an increase in severe Strep A infections in most countries. Many of these cases have been reported in the news. Human challenge models are studies which allow researchers to study organisms that cause infections in humans. In this human challenge model study, healthy participants will be carefully exposed to a specific type of Strep A under controlled conditions to cause sore throat and learn more about how Strep A causes infection. The study team has already developed a safe human challenge model using a strain of Strep A called M75. This study will use a different strain of Strep A, called M1. The main goal of this study is to check if the procedure is safe for participants and to understand how the participant's body responds to M1 Strep A. The study will explore: 1. How much M1 Strep A is required to cause an infection. 2. How M1 Strep A grows in the body. 3. How the body reacts to M1 Strep A. The information the investigators will get about M1 Strep A from this study will help plan future research. It may also help in designing better studies to test vaccines against Strep A.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT06992141
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06992141 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Murdoch Childrens Research Institute
- Last refreshed: 16 March 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06992141.
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