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NCT06991595: REAdME
Fertility Limiting Diseases of Pelvic Organs and Their Influence on Receptivity of Endometrial Cavity: Prospective Clinical Trial
trial testing cytoreductive resection of adenomyosis, myomectomy, resection of endometriosis in Adenomyosis in 236 participants. Currently enrolling.
1 April 2026
Quick facts
| Lead sponsor | Charles University, Czech Republic |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 236 |
| Start date | 1 April 2023 |
| Primary completion | 1 April 2026 |
| Estimated completion | 31 December 2026 |
| Sites | 1 location across Czechia |
Drugs / interventions tested
- cytoreductive resection of adenomyosis, myomectomy, resection of endometriosis
- hysteroscopy
Conditions studied
- Adenomyosis — all drugs for Adenomyosis →
- Fibroid Uterus — all drugs for Fibroid Uterus →
- Endometriosis — all drugs for Endometriosis →
Sponsor
Charles University, Czech Republic
Who can join
Adults 18 to 45, female only, with Adenomyosis or Fibroid Uterus. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In this project, we will characterize the effects of fertility limiting diseases of pelvic organs on the receptivity of the endometrium. The primary aim of the project is the characterization of endometrium in patients with infertility suffering from AD, UF and DE, and compare it with infertile patients with minimal or mild endometriosis but no AD or UF (ETRS group), and with healthy women with only male factor of infertility (CTRL group, controls). The proper infertility treatment of patients with AD,UF and endometriosis is controversial and lacking clear evidence based algorithms. Despite their topical character, especially AD and DE (and UFs as well if present as multiple lesions) can be classified as systemic diseases in relation to women´s fertility. The presumed impact of these pathologies to endometrial receptivity (no matter they do not occur in the uterine cavity itself) can beseen as a fascinating hypothesis. Eradication of these diseases could have a potential to increase the prognosis of these women fundamentally.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06991595
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Adenomyosis
Currently open trials in the same condition.
- NCT07455721 — Central Sensitization in Women With Adenomyosis: Prevalence, Risk Factors, and Therapeutic Failure · active not recruiting
- NCT07486622 — Transvaginal Electromechanical Fragmentation and Removal of Large Uterus in a Sealed Bag: The First Group of Clinical St · active not recruiting
- NCT06572852 — Next-Generation Endometriosis Diagnostics Through Comprehensive Multi-Dimensional Analysis · recruiting
- NCT06364592 — Electroacupuncture for Dysmenorrhea Secondary to Adenomyosis · NA · recruiting
- NCT06604091 — Cohort Profile：The Shandong Adenomyosis Cohort of Population Undergoing Reproductive Technology (SAart) · active not recruiting
Other Charles University, Czech Republic trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06991595 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Charles University, Czech Republic
- Last refreshed: 28 May 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06991595.
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