Last reviewed · How we verify
NCT06984601: RELIEF
RELIEF Study: Resolving Fissures With Lateral Internal Sphincterotomy
trial testing Lateral Internal Sphincterotomy (LIS) in Chronic Anal Fissure in 300 participants. Not yet recruiting.
31 May 2026
Quick facts
| Lead sponsor | Turkish Society of Colon and Rectal Surgery |
|---|---|
| Status | Not yet recruiting |
| Study type | OBSERVATIONAL |
| Enrollment | 300 |
| Start date | 1 June 2025 |
| Primary completion | 31 May 2026 |
| Estimated completion | 31 May 2027 |
Drugs / interventions tested
- Lateral Internal Sphincterotomy (LIS)
Conditions studied
- Chronic Anal Fissure — all drugs for Chronic Anal Fissure →
Sponsor
Turkish Society of Colon and Rectal Surgery
Who can join
18 and older, any sex, with Chronic Anal Fissure. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this observational study is to learn how a common surgery called lateral internal sphincterotomy (LIS) affects people with chronic anal fissures, a painful tear near the anus. The study will look at whether this surgery helps lower problems like pain and incontinence, and how it affects quality of life and mental health. The main questions the study aims to answer are: Does LIS surgery lower the rate of incontinence one year after surgery? Does it improve quality of life, reduce pain, and increase patient satisfaction? Participants will: Have surgery for chronic anal fissure called LIS. Complete short surveys about pain and mental health at 1 week, 3 months, and 12 months. Answer questions about bowel function, incontinence and daily life at 3 and 12 months. Researchers will follow about 300 adults at hospitals across the Turkey. This study will help improve future treatment decisions and make surgery safer and more effective.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06984601
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Chronic Anal Fissure
Currently open trials in the same condition.
- NCT07268261 — Combined Method of Surgical Treatment of Anal Fissure · NA · recruiting
Other Turkish Society of Colon and Rectal Surgery trials
Trials by the same sponsor.
- NCT06823297 — Can Neoadjuvant Chemoradiotherapy be Ommited in Mid-rectal Cancer · not yet recruiting
- NCT06902701 — Endoscopic Submucosal Dissection vs. Transanal Endoscopic Surgery for Rectal Neoplasia · not yet recruiting
- NCT06971107 — Current Microsatellite Stability Results in Colon Cancer · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06984601 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Turkish Society of Colon and Rectal Surgery
- Last refreshed: 22 May 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06984601.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing