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NCT06984315
Effects of Anesthesia Type on Inflammatory Response
trial testing The effects of the groups on perioperative inflammation changes were compared. in Spinal Aneshtesia in 849 participants. Completed in 10 May 2025.
1 April 2025
Quick facts
| Lead sponsor | Tokat Gaziosmanpasa University |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 849 |
| Start date | 1 January 2020 |
| Primary completion | 1 April 2025 |
| Estimated completion | 10 May 2025 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- The effects of the groups on perioperative inflammation changes were compared.
Conditions studied
- Spinal Aneshtesia — all drugs for Spinal Aneshtesia →
- General Anesthetic — all drugs for General Anesthetic →
- Inflammation — all drugs for Inflammation →
- Neutrophils — all drugs for Neutrophils →
Sponsor
Tokat Gaziosmanpasa University
Who can join
Adults 18 to 75, any sex, with Spinal Aneshtesia or General Anesthetic. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In total knee arthroplasty, surgical and anesthetic procedures can lead to a significant increase in systemic inflammation. This procedure is frequently performed under either general or spinal anesthesia. However, studies investigating the effect of anesthesia type on systemic inflammation have shown conflicting results. The Systemic Inflammatory Response Index (SIRI) and the Systemic Immune-Inflammation Index (SII) provide important information about the extent of systemic inflammation. This study aimed to investigate the effects of general and spinal anesthesia on perioperative changes in SII and SIRI during total knee arthroplasty. Between January 2020 and April 2025, data from 849 patients who underwent total knee arthroplasty were retrospectively reviewed. Patients received either spinal anesthesia (Group S) or general anesthesia (Group G). The groups were compared in terms of changes in perioperative SII and SIRI (ΔSII and ΔSIRI), total opioid consumption, postoperative complications, and length of hospital stay.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Comparison of systemic inflammatory markers in total knee arthroplasty under spinal vs general anesthesia: a retrospective study.
Genç A, Astan S, Gürler Balta M, Kölükçü V, et al · · 2025 · PMID 41126033 · DOI 10.1186/s12871-025-03399-y
Verify or expand the search:
- PubMed search for NCT06984315
- Europe PMC full search
- ASCO Meeting Library
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06984315 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Tokat Gaziosmanpasa University
- Last refreshed: 25 May 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06984315.
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