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NCT06978712
Impact of Periodontal Inflammation on Allostatic Load
NA trial testing Sub-gingival instrumentation in Allostatic Load in 112 participants. Not yet recruiting.
10 June 2026
Quick facts
| Lead sponsor | Postgraduate Institute of Dental Sciences Rohtak |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 112 |
| Start date | 10 June 2025 |
| Primary completion | 10 June 2026 |
| Estimated completion | 1 December 2026 |
| Sites | 1 location across India |
Drugs / interventions tested
- Sub-gingival instrumentation
Conditions studied
- Allostatic Load — all drugs for Allostatic Load →
- Periodontitis, Chronic — all drugs for Periodontitis, Chronic →
Sponsor
Postgraduate Institute of Dental Sciences Rohtak
Who can join
Adults 30 to 50, any sex, with Allostatic Load or Periodontitis, Chronic. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Periodontitis is a prevalent global health issue that contributes to systemic inflammation and is closely linked to stress as a risk factor. Both conditions have been investigated for bidirectional relationship. However, the results are inconsistent, and the mechanistic links remain unclear. Allostatic load, which measures the cumulative biological effects of stress, may be relevant in elucidating this connection. Inconsistent results have been reported in previous studies exploring the association between periodontitis and individual biomarkers of allostatic load. Furthermore, none of these studies has taken into consideration staging and grading of periodontitis. Additionally, while periodontal treatment has been shown to reduce both local and systemic inflammation, its effect on allostatic load remains unexplored till date. This study aims to fill these gaps by evaluating the relationship between these parameters of periodontitis and allostatic load. Evaluation of impact of subgingival instrumentation on allostatic load may further provide insights into the broader systemic benefits of periodontal interventions.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06978712
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Postgraduate Institute of Dental Sciences Rohtak trials
Trials by the same sponsor.
- NCT07412067 — Healing of Apicomarginal Defects Using Autograft or Allograft With Collagen Membrane · NA · not yet recruiting
- NCT07381595 — Role of Subgingival Instrumentation in Oral Lichen Planus · NA · not yet recruiting
- NCT07300124 — Outcome of Direct Pulp Capping and Partial Pulpotomy in Reversible Pulpitis · NA · not yet recruiting
- NCT07506135 — Effect of Aromatherapy on Pain and Anxiety During Orthodontic Extraction of Maxillary Premolars. · NA · completed
- NCT07179835 — To Evaluate Periapical Healing Post Full Pulpotomy in Teeth With and Without Apical Periodontitis · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06978712 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Postgraduate Institute of Dental Sciences Rohtak
- Last refreshed: 18 May 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06978712.
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