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NCT06977230
Remote Ischemic Preconditioning in Type 2 Diabetic Patients Undergoing CABG
NA trial testing Remote Ischemic Preconditioning in Diabetes Mellitus in 60 participants. Currently enrolling.
30 July 2025
Quick facts
| Lead sponsor | Muğla Sıtkı Koçman University |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | prevention |
| Enrollment | 60 |
| Start date | 26 May 2025 |
| Primary completion | 30 July 2025 |
| Estimated completion | 15 September 2025 |
| Sites | 2 locations across Turkey (Türkiye) |
Drugs / interventions tested
- Remote Ischemic Preconditioning
Conditions studied
- Diabetes Mellitus — all drugs for Diabetes Mellitus →
- Coronary Artery Bypass — all drugs for Coronary Artery Bypass →
- Remote Ischaemic Conditioning — all drugs for Remote Ischaemic Conditioning →
Sponsor
Muğla Sıtkı Koçman University
Who can join
Adults 45 to 85, any sex, with Diabetes Mellitus or Coronary Artery Bypass. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This randomized, double-blind, prospective clinical trial aims to investigate the effect of remote ischemic preconditioning (RIPC) on myocardial protection in patients with type 2 diabetes mellitus undergoing elective coronary artery bypass graft (CABG) surgery. Perioperative myocardial injury remains a significant concern during CABG, particularly in high-risk patients such as those with diabetes. RIPC is a low-cost, non-invasive intervention that may reduce myocardial damage by enhancing ischemic tolerance through intermittent limb ischemia. Sixty patients aged 40-85 years with type 2 diabetes scheduled for isolated CABG will be randomized to either receive RIPC or standard care. RIPC will be applied through five cycles of upper limb cuff inflation and deflation prior to sternotomy. High-sensitivity troponin T levels will be measured at 24, 48, and 72 hours postoperatively to assess myocardial injury. Secondary outcomes include acute kidney injury (KDIGO classification), maximum vasoactive-inotropic score (VIS) during the first 72 postoperative hours, ICU and hospital length of stay. This study will provide insight into the cardioprotective role of RIPC in diabetic patients undergoing cardiac surgery.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06977230
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
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Related trials
Other trials of Remote Ischemic Preconditioning
Trials testing the same drug.
- NCT05147831 — Effectiveness of Remote Ischemic Preconditioning for Prevention of Contrast Induced Acute Kidney Injury in Patients Unde · NA · recruiting
- NCT05082207 — Ischemic Preconditioning and Thiol-disulfide Balance · NA · completed
- NCT03853473 — Prehabilitation of Frail Surgical Cancer Patients Using Remote Ischemic Preconditioning · NA · completed
- NCT03273751 — The Effect of Remote Ischemic Preconditioning on Kidney Function in Patients Undergoing Partial Nephrectomy · NA · completed
- NCT04174261 — Ticagrelor in Remote Ischemic Preconditioning Study · Phase 4 · completed
Other recruiting trials for Diabetes Mellitus
Currently open trials in the same condition.
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- NCT07392437 — Prevalence of Diabetes-related Distress Among Patients Living With Type 2 Diabetes in a University Hospital Center and I · NA · recruiting
- NCT07448805 — Accuracy and Safety of the Syai Tag System for Continuous Glucose Monitoring in Intensive Internal Care Unit · NA · recruiting
- NCT07425275 — Integrated Oral Care Intervention for Xerostomia in Diabetes Patients · NA · recruiting
- NCT06918977 — Improving Glycemic Control With Telemedicine and Smart Insulin Pens · NA · recruiting
Other Muğla Sıtkı Koçman University trials
Trials by the same sponsor.
- NCT05046834 — Effect of Cold Application on Patient's Pain and Vital Signs During Chest Tube Removal. · NA · withdrawn
- NCT07323160 — Determining the Effect of Education Given to Patients Undergoing Outpatient Anal Fistula Surgery · NA · not yet recruiting
- NCT07308730 — Pain Diary Use After Laparoscopic Cholecystectomy · NA · recruiting
- NCT06704399 — Psychoeducation Based on Acceptance and Commitment Therapy · NA · not yet recruiting
- NCT07183956 — Comparison of the Silverman-Andersen Score and the Downes Score · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06977230 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Muğla Sıtkı Koçman University
- Last refreshed: 18 June 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06977230.
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