NCT06976554

Mechanical Ventilator Weaning in Chronically Ventilated Patients

Completed NA Last updated 3 August 2025

What this trial tests

NA trial testing weaning in Mechanical Ventilation Complication in 51 participants. Completed in 29 July 2025.

Timeline

1 September 2023

Primary endpoint
30 June 2025

29 July 2025

Quick facts

Lead sponsor	University of California, Los Angeles
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	51
Start date	1 September 2023
Primary completion	30 June 2025
Estimated completion	29 July 2025
Sites	1 location across United States

Drugs / interventions tested

• weaning

Conditions studied

• Mechanical Ventilation Complication — all drugs for Mechanical Ventilation Complication →

Sponsor

University of California, Los Angeles

Who can join

Eligibility, any sex, with Mechanical Ventilation Complication. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Mechanical ventilation is a commonly used life-saving hospital procedure for patients with severe breathing difficulty. Some patients have difficulty separating from the ventilator and need to be removed gradually. This process is called ventilator weaning. It is not known what is the best way to wean patients from the ventilator. In this study, the investigators will compare two commonly used ventilator weaning strategies and compare their success. One ventilator strategy, the Pressure Support Ventilation weaning (PSV), combines 12 hours ventilator weaning with 12 hours rest on the ventilator. This strategy is faster with an anticipated weaning in 2 weeks. The other strategy, the Therapist implemented Patient Specific weaning (TIPS), gradually lowers support and weans in 3 weeks.

Patients admitted to Barlow Respiratory Hospital (BRH) for ventilator weaning will be asked to participate in this study within 72 hours of hospital admission. Participants will undergo a spontaneous breathing trial (SBT) to assess your ability to breathe while receiving minimal or no ventilator support. Patients who pass SBT will be eligible for cool aerosol trials (humidified, oxygenated air without positive pressure mechanical ventilation). Participants who fail SBT within 24 hours will be eligible for the study. Participants will be randomized to receive PSV or TIPS ventilator weaning. The investigators will collect clinical, laboratory and mechanical ventilator information throughout the study period. Ventilator weaning success will be compared at day 30. The study will not interfere with any components of clinical care but the study investigators will be allowed to change the ventilator weaning strategy from PSV to TIPS, if a participant is unable to tolerate PSV weaning.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Randomized clinical trial of ventilator liberation with pressure support ventilation versus therapist-implement patient-specific weaning in prolonged weaning patients via tracheostomy.
   Dolinay T, Jun D, Gogineni S, Hsu L, et al · · 2026 · PMID 42104281 · DOI 10.1186/s12890-026-04341-9