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NCT06973148

Evaluation of Oxidative Stress and Methylated Arginine Levels in Individuals With Periodontitis

Completed Last updated 15 May 2025
What this trial tests

trial in Periodontitis in 40 participants. Completed in 19 December 2022.

Timeline
7 June 2021
Primary endpoint
19 December 2022
19 December 2022

Quick facts

Lead sponsorAnkara Medipol University
StatusCompleted
Study typeOBSERVATIONAL
Enrollment40
Start date7 June 2021
Primary completion19 December 2022
Estimated completion19 December 2022
Sites1 location across Turkey (Türkiye)

Conditions studied

Sponsor

Ankara Medipol University

Who can join

Adults 18 to 64, any sex, with Periodontitis or Oxidative Stress. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

You are being invited to participate in a scientific research study. Before you decide to take part, it is essential that you understand why the study is being conducted and what your participation will involve. Please take the time to read the following information carefully. Feel free to ask if anything is unclear or need more details. This study aims to evaluate saliva composition, specifically focusing on amino acid and protein building blocks, oxidative stress, and the Nitric Oxide metabolism system, including levels of ADMA (Asymmetric Dimethylarginine) and SDMA (Symmetric Dimethylarginine). By examining these parameters, we aim to contribute to a better understanding of the biological mechanisms involved in gum health and systemic responses. You have been selected to participate in this study based on your periodontal (gum) health status. A total of 40 individuals, 20 diagnosed with periodontitis and 20 diagnosed as periodontally healthy, who meet the study criteria, will be included. If you choose to participate, you will receive non-surgical periodontal treatment as part of your routine care. Before the treatment, biological samples, including saliva and serum, will be collected. These samples will be used solely for scientific analysis and will not affect the outcome of your dental treatment. Although the total duration of the study is 2 years, your involvement will conclude at the beginning of periodontal therapy. There are no anticipated risks associated with participation beyond those commonly encountered during dental examinations and treatments. You will not benefit directly; however, your contribution will help advance scientific knowledge about the factors influencing oral and systemic health. All information collected from you during the study will remain confidential. Your identity will be protected, and personal data will not be disclosed in any reports or publications resulting from this study. Participation in this study is entirely voluntary. You are free to decline or withdraw at any time, without needing to give a reason. Your decision will not affect the quality of care you receive. All tests, examinations, and procedures performed as part of this study will be provided at no cost to you. Participation will not result in any financial cost or compensation.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

  1. Interaction between methylated arginine metabolites and oxidative stress in periodontitis: a cross-sectional study.
    Balkan B, Guney Z, Balkan E, Balkan EP, et al · · 2025 · cited 1× · PMID 41239382 · DOI 10.1186/s12903-025-06972-6

Verify or expand the search:

Other recruiting trials for Periodontitis

Currently open trials in the same condition.

Other Ankara Medipol University trials

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Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06973148.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing