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NCT06968832: PROJECT COMET
Project COMET: Massed Prolonged Exposure for PTSD and SUD
NA trial testing Massed Prolonged Exposure Therapy (M-PE) in Posttraumatic Stress Disorder (PTSD) in 168 participants. Currently enrolling.
30 June 2029
Quick facts
| Lead sponsor | Rutgers, The State University of New Jersey |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 168 |
| Start date | 2 September 2025 |
| Primary completion | 30 June 2029 |
| Estimated completion | 30 June 2029 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Massed Prolonged Exposure Therapy (M-PE)
- Standard outpatient SUD care
Conditions studied
- Posttraumatic Stress Disorder (PTSD) — all drugs for Posttraumatic Stress Disorder (PTSD) →
- Substance Use Disorders (SUD) — all drugs for Substance Use Disorders (SUD) →
- Comorbidity — all drugs for Comorbidity →
- Trauma and Stressor Related Disorders — all drugs for Trauma and Stressor Related Disorders →
Sponsor
Rutgers, The State University of New Jersey
Who can join
18 and older, any sex, with Posttraumatic Stress Disorder (PTSD) or Substance Use Disorders (SUD). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this clinical trial is to learn if Massed Prolonged Exposure Therapy (M-PE) can improve PTSD symptoms and reduce substance use in adults receiving intensive outpatient (IOP) treatment for substance use disorder (SUD). The main questions it aims to answer are: * Does M-PE reduce PTSD symptoms more effectively than trauma treatment as usual (TAU)? * Does M-PE reduce the number of days participants use substances? * How do patient-centered outcomes (such as depression, suicidal thoughts, and quality of life) differ between M-PE and trauma TAU? * Researchers will compare M-PE to treatment as usual to see if M-PE leads to better mental health and substance use outcomes and lower dropout rates. Participants will: * Attend multiple therapy sessions per week (M-PE) or receive usual care * Complete assessments at baseline, during treatment, end-of-treatment, 1-month, 3-month, and 6-month follow-up * Share feedback through surveys and interviews about their experience in the program
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06968832
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06968832 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Rutgers, The State University of New Jersey
- Last refreshed: 27 October 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06968832.
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