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NCT06968663
Transcranial Magnetic Stimulation + Language Therapy to Treat Subacute Aphasia
Phase 2 trial testing Transcranial Magnetic Stimulation (TMS) in Stroke in 63 participants. Currently enrolling.
31 July 2029
Quick facts
| Lead sponsor | University of Pennsylvania |
|---|---|
| Phase | Phase 2 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 63 |
| Start date | 1 August 2024 |
| Primary completion | 31 July 2029 |
| Estimated completion | 31 July 2029 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Transcranial Magnetic Stimulation (TMS)
- Modified Constraint Induced Language Therapy (mCILT)
Conditions studied
- Stroke — all drugs for Stroke →
- Aphasia — all drugs for Aphasia →
- Aphasia Following Cerebral Infarction — all drugs for Aphasia Following Cerebral Infarction →
Sponsor
University of Pennsylvania
Who can join
Adults 18 to 85, any sex, with Stroke or Aphasia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this clinical trial is to determine if Transcranial Magnetic Stimulation (TMS) combined with modified Constraint Induced Language Therapy (mCILT) is an effective treatment for aphasia when delivered in the subacute stage after stroke. The main questions this study aims to answer are: 1. Can TMS combined with mCILT improve overall speech? 2. Can we identify specific behavioral and biological characteristics that would benefit most from the TMS and mCILT treatment? Researchers will compare real TMS to sham (fake) TMS to see whether TMS can treat subacute aphasia. Importantly, this trial will use electric field guided TMS to identify optimal and individualized stimulation intensity and site targeting. Participants will: * Complete a screening and medical intake to determine eligibility * Undergo MRI scans * Participate in 10 consecutive sessions (Monday-Friday) of TMS and mCILT treatment * Complete follow-up assessments immediately and 4 months after treatment
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06968663
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Currently open trials in the same condition.
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Other University of Pennsylvania trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06968663 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Pennsylvania
- Last refreshed: 18 May 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06968663.
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