NCT06968533: ELEGANT

ECG Low Ejection Fraction Detection and Guiding in AI Navigated Treatment Era

ENROLLING BY INVITATION NA Last updated 21 May 2025

What this trial tests

NA trial testing AI-ECG guided diagnosis in Heart Failure in 13,350 participants. Enrolling by invitation.

Timeline

1 June 2024

Primary endpoint
1 June 2027

1 June 2027

Quick facts

Lead sponsor	National Defense Medical Center, Taiwan
Phase	NA
Status	ENROLLING BY INVITATION
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	screening
Enrollment	13,350
Start date	1 June 2024
Primary completion	1 June 2027
Estimated completion	1 June 2027
Sites	1 location across Taiwan

Drugs / interventions tested

• AI-ECG guided diagnosis

Conditions studied

• Heart Failure — all drugs for Heart Failure →
• Ventricular Dysfunction, Left — all drugs for Ventricular Dysfunction, Left →
• Artificial Intelligence — all drugs for Artificial Intelligence →
• Early Diagnosis — all drugs for Early Diagnosis →

Sponsor

National Defense Medical Center, Taiwan

Who can join

Adults 60 to 85, any sex, with Heart Failure or Ventricular Dysfunction, Left. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Asymptomatic left ventricular systolic dysfunction (ALVSD), identified as a key component of stage B heart failure (HF) by AHA/ACC guidelines, is a common precursor to clinically overt HF. This progressive chronic disease affects over 23 million people worldwide and leads to significant morbidity, mortality, and healthcare costs. Although ALVSD presents a relatively lower risk compared to symptomatic reduced ejection fraction HF, it remains associated with a 1.6-fold increase in the risk of incident HF, a 2.13-fold increase in cardiovascular mortality, and a 1.46-fold increase in all-cause mortality. The prevalence of ALVSD ranges from 3% to 6%, at least twice that of symptomatic HF. To prevent progression to symptomatic heart failure and associated morbidities and mortalities, guideline-directed medical therapy, including ACEIs/ARBs or beta-blockers, is essential for patients with ALVSD. However, distinguishing individuals with ALVSD from the general population is challenging due to the lack of symptoms. Effective screening methods are crucial to identify individuals with ALVSD. Traditionally, diagnosing ALVSD involves screening asymptomatic populations using transthoracic echocardiography (TTE), which is costly, time-consuming, and inconvenient for patients. Other screening methods, such as laboratory tests for brain natriuretic peptide (BNP) or N- terminal pro-atrial natriuretic peptide (NT-proBNP), have insufficient diagnostic performance.

Previous research proposed an AI-based alarm system (AI-S) to screen patients for ALVSD, demonstrating greater accuracy than BNP screening and improved accessibility compared to widespread echocardiography. AI-S demonstrated a sensitivity of 92.6% (standard error \[SE\] 0.042) for detecting medium-risk ALVSD patients and 63% (SE 0.154) for high-risk ALVSD patients, with a specificity of 92.7% (SE 0.003) for medium-risk patients and 98.7% (SE 0.002) for high-risk patients. AI-S is accuracy, noninvasive, highly accessible in local medical clinics, less time-consuming, and cost-effective, making it a valuable screening tool for identifying ALVSD prior to echocardiography or other confirmatory diagnostic methods.

To date, no randomized controlled trial has assessed the cost-effectiveness and impact of AI-assisted screening tools for heart failure prevention in Asians. The ECG AI-Guided Screening for Low Ejection Fraction (EAGLE) trial reported a 32% increase in diagnosing of low left ventricular ejection fraction (defined as LVEF ≤50%) within 90 days of the ECG. However, this population was not Asian, and randomization involved primary care teams rather than participants. Therefore, this randomized controlled trial is designed to evaluate the impact of AI-S on diagnosing low ejection fraction in Asians, its cost-effectiveness, and the incidence of worsening HF (defined as admission for HF or HF-related emergency department visits).

Publications & conference data

No peer-reviewed publications indexed yet for this trial.