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NCT06960044: PCT
Procalcitonin Aided Antimicrobial Therapy vs Standard of Care
NA trial testing Procalcitonin-guided antibiotic management in Lower Respiratory Tract Infection (LRTI) in 108 participants. Not yet recruiting.
1 December 2026
Quick facts
| Lead sponsor | Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | health services research |
| Enrollment | 108 |
| Start date | 1 June 2025 |
| Primary completion | 1 December 2026 |
| Estimated completion | 1 June 2027 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- Procalcitonin-guided antibiotic management
- Standard of care
Conditions studied
- Lower Respiratory Tract Infection (LRTI) — all drugs for Lower Respiratory Tract Infection (LRTI) →
Sponsor
Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria — full company profile →
Who can join
18 and older, any sex, with Lower Respiratory Tract Infection (LRTI). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Antibiotic resistance is driven by overuse, especially for viral respiratory infections. Procalcitonin (PCT), a biomarker for bacterial infections, helps guide antibiotic therapy more precisely, reducing unnecessary use and improving outcomes. Studies, including large trials and economic models across several countries, show PCT-guided treatment lowers mortality, antibiotic exposure, therapy duration and related complications, potentially reducing hospital costs despite initial testing expenses.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06960044
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Lower Respiratory Tract Infection (LRTI)
Currently open trials in the same condition.
- NCT07249996 — Respiratory Infections in Young Children · recruiting
Other Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria trials
Trials by the same sponsor.
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- NCT06296277 — Mechanical Ventilation in Surgical Patients · not yet recruiting
- NCT07252076 — PRetreatment MRI for OCcult Liver Metastasis Assessment In Pancreatic Ductal adenocarcinoMa · recruiting
- NCT07150871 — Impact of Covid-19 on Syphilis · active not recruiting
- NCT07529730 — Outcomes of Surgical Treatment in Patients With Infective Endocarditis · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06960044 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
- Last refreshed: 7 May 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06960044.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing