Neuroimmunology Registry and Biobank

NCT06958341 RECRUITING

A variety of antineuronal antibodies have been detected in the cerebrospinal fluid (CSF) of patients with neurological diseases. This raises the question of whether these antibodies are disease-specific or merely an epiphenomenon of inflammatory processes in the brain. The registry was established with the following objectives: \[1\] Are antineuronal antibodies much more common than previously thought in various neurological disorders for which the etiology has not yet been elucidated? \[2\] Can further correlations, such as those between HSV infection and NMDA receptor autoimmunity, be identified? \[3\] Are these antibodies mainly non-specific epiphenomena or are they crucial for the pathogenesis? \[4\] What is the clinical course of patients with antineuronal antibodies and their response to therapy? These questions will be addressed in a broad immunohistological screening of a large number of CSF samples and a clinical database of patients with neurological disorders.

Details

Lead sponsor	Charite University, Berlin, Germany
Status	RECRUITING
Enrolment	300
Start date	Mon Feb 01 2021 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Tue Jul 01 2031 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

• Encephalopathy
• Psychosis
• Impaired Consciousness
• Epilepsy
• Movement Disorders
• Motor Neuropathy
• Spasticity
• Ataxia

Countries

Germany