NCT06958159 (HEIST) is a NA clinical trial of Endoscopic Stricturotomy in Crohn Disease (CD), sponsored by Asian Institute of Gastroenterology, India.

Who is sponsoring NCT06958159?

NCT06958159 is sponsored by Asian Institute of Gastroenterology, India.

What drugs are being tested in NCT06958159?

Interventions in NCT06958159: Endoscopic Stricturotomy, Endoscopic Balloon Dilation.

What condition does NCT06958159 study?

NCT06958159 studies Crohn Disease (CD).

Is NCT06958159 still recruiting?

NCT06958159 is currently recruiting now. Last updated 17 July 2025.

Last reviewed 2025-07-17 · How we verify

NCT06958159: HEIST

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Hybrid Endoscopic Stricturotomy Plus Balloon Dilation Versus Stricturotomy Alone for Short Crohn's Disease Strictures

Recruiting now NA Last updated 17 July 2025

What this trial tests

NA trial testing Endoscopic Stricturotomy in Crohn Disease (CD) in 40 participants. Currently enrolling.

Timeline

29 April 2025

Primary endpoint
15 March 2027

15 May 2027

Quick facts

Lead sponsor	Asian Institute of Gastroenterology, India
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	40
Start date	29 April 2025
Primary completion	15 March 2027
Estimated completion	15 May 2027
Sites	1 location across India

Drugs / interventions tested

Endoscopic Stricturotomy
Endoscopic Balloon Dilation

Conditions studied

Crohn Disease (CD) — all drugs for Crohn Disease (CD) →

Sponsor

Asian Institute of Gastroenterology, India

Who can join

Adults 18 to 65, any sex, with Crohn Disease (CD). Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Crohn's disease is a chronic condition that can lead to inflammation and narrowing (strictures) of the intestine, causing symptoms like pain, bloating, and difficulty with bowel movements. These strictures are often treated with endoscopic procedures such as balloon dilation or stricturotomy to widen the narrowed segments and relieve symptoms. The HEIST Study is a randomized clinical trial designed to compare two endoscopic treatment strategies for short Crohn's disease-related strictures (less than 3 centimeters in length). One group will undergo endoscopic stricturotomy alone, while the other group will receive a combination of stricturotomy followed by balloon dilation (hybrid approach). The goal is to determine whether the hybrid approach improves long-term outcomes such as symptom relief, reduced need for repeat procedures, and avoidance of surgery. Patients will be followed for 12 months after treatment to assess durability of response, quality of life, and any complications or additional interventions needed. This study aims to provide high-quality evidence to guide endoscopic treatment of intestinal strictures in Crohn's disease and to help identify the most effective and safest approach for long-term symptom control.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other recruiting trials for Crohn Disease (CD)

Currently open trials in the same condition.

NCT07510191 — TNFi Plus Low-Dose Upadacitinib vs TNFi Intensification in Crohn's Disease With Suboptimal Response · Phase 4 · recruiting
NCT07245394 — Switching to the IL-23 Inhibitor Guselkumab for People With Active IBD Who Previously Used Ustekinumab (SHIFT-IBD) · recruiting
NCT07224113 — Assessment and Educational Intervention to Reduce Ultra-processed Food Consumption in Pediatric Patients With IBD · recruiting
NCT07170462 — Cranberry and Gut Health in Crohn's Disease · EARLY_PHASE1 · recruiting
NCT07195123 — Evaluation of the SMART IBD App in Pediatric IBD · NA · recruiting

Other Asian Institute of Gastroenterology, India trials

Trials by the same sponsor.

NCT07486518 — A Multicentre Prospective Cohort Study of The Gastric Precancerous Epithelial Pathway Using High-Definition Endoscopy An · not yet recruiting
NCT07413822 — A Single-centre Open, Prospective, Pilot Clinical Study to Assess the Safety and Performance of the TIES® Transcutaneous · NA · not yet recruiting
NCT07399652 — Artificial Intelligence-Guided Detection of Blood Vessels to Enhance Safety in Third-Space Endoscopic Procedures · NA · recruiting
NCT07371832 — A Single Center Evaluation of AI Enabled SureForm Robotic Stapler (SureformTM) Compared to Conventional Stapler for Colo · recruiting
NCT07329816 — External, Multicentre Validation of a Machine-Learning Model to Predict Colonic Adenoma in Indian Adults · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06958159 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Asian Institute of Gastroenterology, India
Last refreshed: 17 July 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06958159.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing