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NCT06957249
Clinical Study to Evaluate the Tooth Whitening Efficacy
Phase 3 trial testing Optic White 5%HP ActivShine Toothpaste in Whitening in 80 participants. Completed in 5 May 2025.
3 May 2025
Quick facts
| Lead sponsor | Colgate Palmolive |
|---|---|
| Phase | Phase 3 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 80 |
| Start date | 25 April 2025 |
| Primary completion | 3 May 2025 |
| Estimated completion | 5 May 2025 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Optic White 5%HP ActivShine Toothpaste — full drug profile →
- Crest3DWhite Advanced Radiant Mint Toothpaste — full drug profile →
Conditions studied
- Whitening — all drugs for Whitening →
Sponsor
Colgate Palmolive — full company profile →
Who can join
Adults 18 to 70, any sex, with Whitening. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Optic White 5%HP ActivShine TP vs Crest3D White TP (head-to-head whitening clinical) The objective of this study is to evaluate the tooth whitening efficacy of a Colgate toothpaste with 5% Hydrogen Peroxide and Fluoride compared to a toothpaste with 0% Hydrogen Peroxide and Fluoride over a one-week period.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT06957249
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other Colgate Palmolive trials
Trials by the same sponsor.
- NCT07398846 — Efficacy of a Stannous Fluoride Toothpaste, Cetylpyridinium Chloride Mouthwash, and Battery Toothbrush Regimen in Reduci · Phase 3 · recruiting
- NCT07276672 — Efficacy of a Toothpaste Containing Hydrogen Peroxide as Compared to a Regular Fluoride Toothpaste Without Hydrogen Pero · Phase 3 · completed
- NCT07225478 — Clinical Study to Evaluate the Tooth Whitening Efficacy of a New NextGen In-office Whitening System · Phase 3 · completed
- NCT07224828 — The Efficacy of a Battery Toothbrush in the Reduction of Established Plaque and Gingivitis · Phase 3 · completed
- NCT07134231 — Clinical Study to Evaluate the Anti-cavity Efficacy of Three Dentifrices: An In Situ Model · Phase 3 · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06957249 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Colgate Palmolive
- Last refreshed: 3 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06957249.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing