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NCT06952608
Effect of Ciprofol on Intraoperative Hypotension in Elderly Patients Receiving Renin-angiotensin System Inhibitors
Phase 4 trial testing Ciprofol group in Intraoperative Hypotension in 140 participants. Currently enrolling.
10 February 2026
Quick facts
| Lead sponsor | Second Affiliated Hospital, School of Medicine, Zhejiang University |
|---|---|
| Phase | Phase 4 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | prevention |
| Enrollment | 140 |
| Start date | 10 April 2025 |
| Primary completion | 10 February 2026 |
| Estimated completion | 10 April 2026 |
| Sites | 1 location across China |
Drugs / interventions tested
- Ciprofol group
- Propofol group
Conditions studied
- Intraoperative Hypotension — all drugs for Intraoperative Hypotension →
- Ciprofol — all drugs for Ciprofol →
- Renin-angiotensin System Inhibitors — all drugs for Renin-angiotensin System Inhibitors →
Sponsor
Second Affiliated Hospital, School of Medicine, Zhejiang University
Who can join
65 and older, any sex, with Intraoperative Hypotension or Ciprofol. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The prevention of intraoperative hypotension could reduce postoperative organ injury and mortality, particularly in elderly patients receiving long-term renin-angiotensin system inhibitors. Previous meta-analyses suggest that ciprofol, a novel intravenous anesthetic agent, may provide improved hemodynamic stability compared to propofol; however, its precise effects on perioperative hemodynamics remain unclear. The study will assess whether ciprofol improves perioperative hemodynamic stability in elderly patients receiving renin-angiotensin system inhibitors.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06952608
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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Related trials
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Trials testing the same drug.
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- NCT06172140 — Efficacy and Safety of Ciprofol for the Sedation in Patients Undergoing Hysteroscopy · NA · completed
Other recruiting trials for Intraoperative Hypotension
Currently open trials in the same condition.
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- NCT06091904 — Effects of Sufentanil on the Intraoperative Hemodynamics · NA · recruiting
Other Second Affiliated Hospital, School of Medicine, Zhejiang University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06952608 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Second Affiliated Hospital, School of Medicine, Zhejiang University
- Last refreshed: 30 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06952608.
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