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NCT06952179

Pericardial Histopathology and COVID-19 Seropositivity

Completed Last updated 30 April 2025
What this trial tests

trial in Inflammatory Response in 93 participants. Completed in 1 June 2024.

Timeline
1 February 2023
Primary endpoint
1 February 2024
1 June 2024

Quick facts

Lead sponsorSamsun University
StatusCompleted
Study typeOBSERVATIONAL
Enrollment93
Start date1 February 2023
Primary completion1 February 2024
Estimated completion1 June 2024
Sites1 location across Turkey (Türkiye)

Conditions studied

Sponsor

Samsun University

Who can join

Adults 20 to 75, any sex, with Inflammatory Response or COVID-19. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This prospective study aims to investigate the association between pericardial histopathologic inflammation grades (acute, chronic, or absent) and COVID-19 seropositivity in adult patients undergoing first-time isolated coronary artery bypass grafting (CABG). Pericardial tissue samples were collected during surgery and evaluated histopathologically, while preoperative COVID-19 serological testing was performed. The primary outcome is to determine whether COVID-19 seropositivity is associated with the severity of pericardial inflammation. Patients with prior cardiac surgery, active COVID-19 infection, systemic inflammatory diseases, chronic immunosuppressive therapy, or malignancy were excluded from the study.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

  1. Histopathological Evaluation of the Pericardium in CABG Patients With and Without Prior SARS-CoV-2 Infection: A Prospective Observational Study.
    Ereren E, Ağırbaş H, Karal İH, Koç Şahin S, et al · · 2025 · PMID 41466119 · DOI 10.12659/msm.950106

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Other recruiting trials for Inflammatory Response

Currently open trials in the same condition.

Other Samsun University trials

Trials by the same sponsor.

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Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06952179.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing