NCT06951516

How Simplified Language Affects Comprehension and Learning in Young Children With Down Syndrome

Recruiting now NA Last updated 30 April 2025

What this trial tests

NA trial testing Linguistic simplification in Down Syndrome in 30 participants. Currently enrolling.

Timeline

1 January 2025

Primary endpoint
31 May 2027

31 May 2027

Quick facts

Lead sponsor	Michigan State University
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	30
Start date	1 January 2025
Primary completion	31 May 2027
Estimated completion	31 May 2027
Sites	1 location across United States

Drugs / interventions tested

• Linguistic simplification

Conditions studied

• Down Syndrome — all drugs for Down Syndrome →

Sponsor

Michigan State University

Who can join

Adults 2 to 7, any sex, with Down Syndrome. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The long-term study goal is to experimentally evaluate the components (and likely active ingredients) of early language interventions for young children with Down syndrome (DS). The overall objective is to determine how single-word and telegraphic simplification affects real-time language processing and word learning in young children with DS (relative to full, grammatical utterances). The proposed project will investigate three specific aims: 1) Determine how single-word and telegraphic simplification affects language processing. 2) Determine how single-word and telegraphic simplification affects word learning. 3) Evaluate child characteristics that may moderate the effects of linguistic simplification on language processing and word learning. Aim 1 will test the hypothesis that children with DS will process grammatical utterances faster and more accurately than telegraphic or single-word utterances. Aim 2 will test the hypothesis that overall, children will demonstrate better word learning in the grammatical compared to the single-word and telegraphic conditions. Aim 3 will test the hypothesis that receptive language and nonverbal cognitive abilities will be significant moderators, such that children with stronger linguistic and cognitive skills will show the greatest benefit from grammatical input but children with lower linguistic and cognitive scores will perform similarly across conditions.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.