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NCT06944184
Antibiotic Elution After Two-stage Knee Revision
trial testing Intraarticular microdialysis in Periprosthetic Knee Infection in 10 participants. Completed in 20 July 2024.
24 May 2024
Quick facts
| Lead sponsor | University Hospital, Bonn |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 10 |
| Start date | 31 January 2024 |
| Primary completion | 24 May 2024 |
| Estimated completion | 20 July 2024 |
| Sites | 1 location across Germany |
Drugs / interventions tested
- Intraarticular microdialysis
Conditions studied
- Periprosthetic Knee Infection — all drugs for Periprosthetic Knee Infection →
Sponsor
University Hospital, Bonn
Who can join
18 and older, any sex, with Periprosthetic Knee Infection. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this observational study is to monitor the eluted antibiotic concentrations of gentamicin and vancomycin by a static knee cement spacer in patients being treated for periprosthetic infections of the knee. The main question aims to answer if eluted antibiotics are in a therapeutic range for treatment at sight of infection. Secondarily, local antibiotic concentrations are compared with systemic blood levels, as are systemically applied antibiotics compared to intra-articular concentrations. Intra-articular samples are collected over a 72 hour postoperative period.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT06944184
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Periprosthetic Knee Infection
Currently open trials in the same condition.
- NCT07299565 — Analysis of Pharmacological Aspects Regarding Infection Free Survival After Surgical Treatment of a Periprosthetic Knee · recruiting
- NCT03435679 — One-stage Versus Two-stage Revision of the Infected Knee Arthroplasty · NA · active not recruiting
Other University Hospital, Bonn trials
Trials by the same sponsor.
- NCT07291765 — Blood Flow Restriction Training in Acute Geriatric Rehabilitation: A Randomized Controlled Trial on Its Effects and Safe · NA · not yet recruiting
- NCT07324330 — Slowing Cognitive Decline in Alpha-synucleinopathies by Enhancing Physical Activity · NA · recruiting
- NCT07299591 — Analysis of Pharmacological Aspects Regarding Infection Free Survival After Surgical Treatment of a Periprosthetic Hip I · recruiting
- NCT07299565 — Analysis of Pharmacological Aspects Regarding Infection Free Survival After Surgical Treatment of a Periprosthetic Knee · recruiting
- NCT07043569 — Clinical-randomized Trial of the Effect of Rehabilitation Therapy Using Strength and Blood Flow Restriction Training on · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06944184 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Bonn
- Last refreshed: 25 April 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06944184.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing