NCT06939335 (Lazarus-PEEP) is a Phase 3 clinical trial of Disposable PEEP Valve set at 5 cm H20. in Cardiac Arrest (CA), sponsored by University Hospital, Ghent.

Who is sponsoring NCT06939335?

NCT06939335 is sponsored by University Hospital, Ghent.

What drugs are being tested in NCT06939335?

Interventions in NCT06939335: Disposable PEEP Valve set at 5 cm H20., Controle.

What condition does NCT06939335 study?

NCT06939335 studies Cardiac Arrest (CA), Out-of-hospital Cardiac Arrest (OHCA), Positive End-expiratory Pressure (PEEP), Ventilation During Resuscitation.

Is NCT06939335 still recruiting?

NCT06939335 is currently recruiting now. Last updated 21 January 2026.

Last reviewed 2026-01-21 · How we verify

NCT06939335: Lazarus-PEEP

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Application of Positive End-Expiratory Pressure in Out-of-Hospital Cardiac Arrest: The Lazarus-PEEP Trial.

Recruiting now Phase 3 Last updated 21 January 2026

What this trial tests

Phase 3 trial testing Disposable PEEP Valve set at 5 cm H20. in Cardiac Arrest (CA) in 132 participants. Currently enrolling.

Timeline

25 April 2025

Primary endpoint
1 June 2026

1 February 2027

Quick facts

Lead sponsor	University Hospital, Ghent
Phase	Phase 3
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	132
Start date	25 April 2025
Primary completion	1 June 2026
Estimated completion	1 February 2027
Sites	7 locations across Belgium, France

Drugs / interventions tested

Disposable PEEP Valve set at 5 cm H20.
Controle

Conditions studied

Cardiac Arrest (CA) — all drugs for Cardiac Arrest (CA) →
Out-of-hospital Cardiac Arrest (OHCA) — all drugs for Out-of-hospital Cardiac Arrest (OHCA) →
Positive End-expiratory Pressure (PEEP) — all drugs for Positive End-expiratory Pressure (PEEP) →
Ventilation During Resuscitation — all drugs for Ventilation During Resuscitation →

Sponsor

University Hospital, Ghent

Who can join

18 and older, any sex, with Cardiac Arrest (CA) or Out-of-hospital Cardiac Arrest (OHCA). Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The goal of this clinical trial is to learn whether using Positive End-Expiratory Pressure (PEEP) during cardiopulmonary resuscitation (CPR) improves outcomes for adults who experience out-of-hospital cardiac arrest, a condition where the heart suddenly stops beating. PEEP is used during ventilation, which may enhance oxygen levels by keeping the airways open throughout CPR. This study aims to determine if using PEEP during CPR helps restart the heart more effectively, improves survival rates, and enhances survival with good neurologic outcomes after a cardiac arrest compared to standard CPR without PEEP. Researchers will randomly assign participants to one of two groups: one receiving CPR with PEEP set at 5 cm of water pressure and the other receiving standard CPR without PEEP. Participants will be treated by emergency medical teams trained in advanced life support, and specialised sensors will measure airflow and airway pressure during resuscitation. Additionally, the study will evaluate potential side effects associated with PEEP, such as increased pressure within the chest or lung injuries. Findings from this trial will guide recommendations on the usage of PEEP in standard CPR practices to potentially improve patient outcomes.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other recruiting trials for Cardiac Arrest (CA)

Currently open trials in the same condition.

NCT07520877 — Effect of AED-optimized Telephone-assisted CPR Instructions on No-flow Time and Chest Compression Fraction · NA · recruiting
NCT07410481 — Trial of Acceptance and Mindfulness-based Exposure Therapy (AMBET) and Present Centered Therapy (PCT) · NA · recruiting
NCT07464938 — New Tools and Predictive Markers in the Prognosis of Hypoxic-ischemic Encephalopathy Following Cardiac Arrest · NA · recruiting
NCT07363772 — Evaluation of Mixed Reality Cardiopulmonary Resuscitation Training · NA · recruiting
NCT07374289 — On Scene ECPR in Ostrava · NA · recruiting

Other University Hospital, Ghent trials

Trials by the same sponsor.

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NCT07327450 — Coaching Doctors and Nurses to Improve Ethical Decision-making in Team · NA · not yet recruiting
NCT07402057 — Implementation and Evaluation of a Program Aimed at Facilitating Palliative Care Conversations · NA · recruiting
NCT07387328 — Validation of New sEMG Electrode Placement Guidelines for the Triceps Surae in Post-stroke Individuals. · not yet recruiting
NCT07237399 — Percutaneous Thermo-ablation for the Treatment of Prostate Cancer Oligometastatasis (TA-P-OLIM) · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06939335 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital, Ghent
Last refreshed: 21 January 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06939335.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing