Last reviewed · How we verify
NCT06939114: ONSITE
Optic Nerve Sonography to Monitor Intracranial Pressure After Ischemic sTrokE - The ONSITE Study
trial in Malignant Media Infarction in 107 participants. Completed in 31 March 2024.
31 March 2024
Quick facts
| Lead sponsor | University of Zurich |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 107 |
| Start date | 1 January 2019 |
| Primary completion | 31 March 2024 |
| Estimated completion | 31 March 2024 |
| Sites | 1 location across Switzerland |
Conditions studied
- Malignant Media Infarction — all drugs for Malignant Media Infarction →
- Stroke — all drugs for Stroke →
- Intracranial Hypertension — all drugs for Intracranial Hypertension →
Sponsor
University of Zurich
Who can join
18 and older, any sex, with Malignant Media Infarction or Stroke. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of the ONSITE study is to investigate whether an increase Optic nerve sheath diameter (ONSD) may help to predict intracranial hypertension (IH) after stroke. IH is a life-threatening complicaitons of malignant middle cerebral artery (MCA) infarction due to space-occupying brain edema. Patients at risk are monitored based on clinical symptoms, which can be difficult due to comorbidities such as delirium or systemic infections, which can hempen clinical judgement. Readily available, non-invasive methods to monitor ICP in stroke patients could help to earlier diagnose rising ICP and facilitate treatment decisions such as hemicraniectomy. This study investigates whether ONSD with optic nerve sonography (ONS) can detect brain edema after stroke.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Optic nerve sheath diameter for prediction of intracranial hypertension after ischemic sTrokE - The ONSITE study.
Baumgartner P, Zahn M, Handelsmann HL, Geier K, et al · · 2026 · PMID 41614531 · DOI 10.1093/esj/23969873251379985 -
Optic nerve sheath diameter for prediction of intracranial hypertension after ischemic sTrokE - The ONSITE study.
Baumgartner P, Zahn M, Handelsmann HL, Geier K, et al · · 2025 · PMID 41024460 · DOI 10.1177/23969873251379985
Verify or expand the search:
- PubMed search for NCT06939114
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06939114 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Zurich
- Last refreshed: 22 April 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06939114.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing