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NCT06937775
Rapid Maxillary Expansion Related Oxidative Stress and Periodontal Results
NA trial testing Periodontal measurements (plaque index, gingival index and probing pocket depth scores ) in Maxillary Expansion in 35 participants. Completed in 10 August 2016.
10 March 2016
Quick facts
| Lead sponsor | Recep Tayyip Erdogan University Training and Research Hospital |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | factorial |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 35 |
| Start date | 10 January 2016 |
| Primary completion | 10 March 2016 |
| Estimated completion | 10 August 2016 |
Drugs / interventions tested
- Periodontal measurements (plaque index, gingival index and probing pocket depth scores )
- Biochemical Sample Supply (Collection of serum and saliva samples)
- Rapid maxillary expansion with Hyrax appliance
Conditions studied
- Maxillary Expansion — all drugs for Maxillary Expansion →
Sponsor
Recep Tayyip Erdogan University Training and Research Hospital
Who can join
Adults 11 to 16, any sex, with Maxillary Expansion. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of this study was to investigate the effects of rapid maxillary expansion on local and systemic oxidative stress levels. Thirty-five volunteer patients (17 females and 18 males) who needed rapid maxillary expansion will be included in the study. Serum and saliva samples will be collected from each patient during four different periods: a week before the treatment (T0), on the day of sutural separation (T1), at the end of the active expansion period (T2), and after the completion of a 3-month retention period (T3). To evaluate the patients' periodontal status, plaque index, gingival index, and probing pocket depth scores will be recorded for each period. 8-hydroxydeoxyguanosine (8-OHdG), total oxidative status (TOS), total antioxidant capacity (TAS), and oxidative stress index (OSI) biomarkers will be evaluated to determine the local and systemic oxidative stress levels.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Rapid maxillary expansion related sutural and dentoalveolar changes provoke early-term oxidative stress.
Kose T, Kiki A, Kose O, Turkeri ON. · · 2026 · PMID 41582185 · DOI 10.1186/s12903-026-07739-3
Verify or expand the search:
- PubMed search for NCT06937775
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Maxillary Expansion
Currently open trials in the same condition.
- NCT07411092 — Three-dimensionally Printed Hyrax Versus Conventional Hyrax for Maxillary Arch Expansion in Adolescents · NA · recruiting
- NCT05743127 — 3D-Printed Versus Laboratory-Fabricated Hyrax Expanders · NA · recruiting
Other Recep Tayyip Erdogan University Training and Research Hospital trials
Trials by the same sponsor.
- NCT07427095 — The Relationship Between Ultra-Processed Food Consumption and Oral Health · not yet recruiting
- NCT07427069 — Chronic Kidney Disease Associated Diet · not yet recruiting
- NCT07462104 — Metabolic Syndrome Associated Diet · not yet recruiting
- NCT07354815 — Metabolic Syndrome-Associated Periodontal Inflammatory Surface Area · not yet recruiting
- NCT07287540 — Anti-inflammatory Nutrition on the Outcomes of Non-surgical Periodontal Therapy · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06937775 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Recep Tayyip Erdogan University Training and Research Hospital
- Last refreshed: 24 July 2025
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