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NCT06936514
Clinical Study on Deep Cervical Lymphatic Trunk Decompression Combined With Mid-Cervical Deep Lymph Node-External Jugular Vein Anastomosis for Alzheimer's Disease Treatment
NA trial testing Bilateral Cervical Deep Lymphatic Trunk Decompression Combined with Mid-Cervical Deep Lymph Node-External Jugular Vein Anastomosis for Alzheimer's Disease in Alzheimer's Disease in 45 participants. Enrolling by invitation.
10 July 2025
Quick facts
| Lead sponsor | Oriental Neurosurgery Evidence-Based-Study Team |
|---|---|
| Phase | NA |
| Status | ENROLLING BY INVITATION |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 45 |
| Start date | 8 January 2025 |
| Primary completion | 10 July 2025 |
| Estimated completion | 10 July 2026 |
| Sites | 1 location across China |
Drugs / interventions tested
- Bilateral Cervical Deep Lymphatic Trunk Decompression Combined with Mid-Cervical Deep Lymph Node-External Jugular Vein Anastomosis for Alzheimer's Disease
Conditions studied
- Alzheimer's Disease — all drugs for Alzheimer's Disease →
Sponsor
Oriental Neurosurgery Evidence-Based-Study Team — full company profile →
Who can join
Adults 50 to 80, any sex, with Alzheimer's Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of this study is to evaluate the feasibility, safety, and efficacy of bilateral deep cervical lymphatic trunk decompression combined with mid and deep cervical lymph node-extracervical vein anastomosis in the treatment of patients with Alzheimer's disease. The study seeks to explore new treatment options that may improve the quality of life for patients with Alzheimer's disease.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Brain lymphatic drainage pathways, deep cervical lymphatic surgery, and current insights: A systematic review.
Lahmar T, Thuau F, Pinard G, Boutoleau-Bretonniere C, et al · · 2026 · cited 2× · PMID 40877101 · DOI 10.1016/j.tjpad.2025.100335
Verify or expand the search:
- PubMed search for NCT06936514
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Currently open trials in the same condition.
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- NCT06965062 — Cervical Lymphatico-Venous Bypass for Treatment of Alzheimer's Disease - Proof of Concept Study (CLyVeB-AD-1 Study) · NA · recruiting
- NCT06871839 — The Clinical Study of Synaptic Plasticity-based Lencanumab for the Treatment of Early Alzheimer's Disease · recruiting
- NCT07205003 — Evaluation of the Link Between Carotid Arterial Wall Viscosity and Major Neurocognitive Disorders · recruiting
Other Oriental Neurosurgery Evidence-Based-Study Team trials
Trials by the same sponsor.
- NCT05396209 — To Evaluate the Therapeutic Efficacy of Hydrated Amniotic Membrane in Promoting Closure of Refractory Macular Holes. · NA · unknown
- NCT03620552 — 18F-S16 PET/CT in Healthy Volunteers and Patients With Neurodegenerative Dementia · EARLY_PHASE1 · unknown
- NCT03555292 — 11C-PIB PET/CT in Patients With Parkinson's Disease and Parkinsonian Dementia Syndromes · Phase 2 · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06936514 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Oriental Neurosurgery Evidence-Based-Study Team
- Last refreshed: 19 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06936514.
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