NCT06934421: ReTaKRA

Revised Targets for Knee Radiofrequency Ablation

Recruiting now Last updated 24 April 2025

What this trial tests

trial testing Ultrasound-Guided Genicular Nerve Radiofrequency Ablation in Osteoarthritis Knee Pain in 60 participants. Currently enrolling.

Timeline

20 March 2025

Primary endpoint
14 July 2028

30 July 2031

Quick facts

Lead sponsor	Centro Hospitalar Universitario do Algarve
Status	Recruiting now
Study type	OBSERVATIONAL
Enrollment	60
Start date	20 March 2025
Primary completion	14 July 2028
Estimated completion	30 July 2031
Sites	2 locations across Portugal

Drugs / interventions tested

• Ultrasound-Guided Genicular Nerve Radiofrequency Ablation

Conditions studied

• Osteoarthritis Knee Pain — all drugs for Osteoarthritis Knee Pain →

Sponsor

Centro Hospitalar Universitario do Algarve

Who can join

18 and older, any sex, with Osteoarthritis Knee Pain. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This research team is doing a study to learn more about a new way to treat long-term knee pain caused by joint damage. They are using a treatment called radiofrequency ablation (RFA). This is a procedure where doctors use heat to stop certain nerves from sending pain signals.

In this study, doctors will use ultrasound to guide a small needle to nerves around the knee, called genicular nerves. Then, they will apply heat to those nerves using radiofrequency energy to help reduce pain.

The team created this new method based on recent studies of knee anatomy. They want to find out if this method can safely reduce pain and help people with knee joint damage move better. The study includes people who have moderate to severe knee damage and still have pain after trying medicine, physical therapy, or joint injections.

Each person in the study will have the treatment once. The research team will follow each person for two years. During this time, people in the study will answer simple questions about their knee pain and how it affects their daily life. The researchers will collect this information before the treatment and several times after it. One week after the procedure, the team will call each person to ask how they are feeling and check for any side effects.

Possible benefits of the study include less knee pain and easier movement. Possible risks include pain during the procedure, bruising, swelling, or short-term worsening of pain. Rare risks include nerve problems, weakness, bone damage, or allergic reaction.

The study is free for participants, and there is no payment. Taking part is voluntary. Anyone can stop being in the study at any time without affecting their medical care. The research team will keep all personal information private and secure.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.