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NCT06932211
A Study to Measure the Effect of a Toothpaste Containing Proteins and Enzymes and a Fluoride Toothpaste on Gingival Health
NA trial testing Toothpaste containing proteins and enzymes in Gingival Inflammation in 251 participants. Completed in 30 April 2019.
30 April 2019
Quick facts
| Lead sponsor | Unilever R&D |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | prevention |
| Enrollment | 251 |
| Start date | 29 October 2018 |
| Primary completion | 30 April 2019 |
| Estimated completion | 30 April 2019 |
| Sites | 1 location across China |
Drugs / interventions tested
- Toothpaste containing proteins and enzymes
- Control fluoride toothpaste
Conditions studied
- Gingival Inflammation — all drugs for Gingival Inflammation →
- Dental Plaque — all drugs for Dental Plaque →
Sponsor
Unilever R&D — full company profile →
Who can join
Adults 18 to 70, any sex, with Gingival Inflammation or Dental Plaque. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study is a double-blind, randomised, parallel group efficacy study. A minimum of 240 healthy female and male participants aged 18-70 years will be enrolled onto the study according to the inclusion/exclusion criteria. The accepted participants will then be randomly allocated to one of the two test products which they will use at home, twice a day for the duration of the study. Dental assessments of gingival condition and plaque level will be conducted after 4, 13 and 26 weeks of product use at the study site.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
The effect of enzyme and protein containing toothpaste on gingival condition: a randomised controlled study.
Hu X, Zhang P, Zhang L, Matheson JR, et al · · 2025 · PMID 41184910 · DOI 10.1186/s12903-025-07096-7
Verify or expand the search:
- PubMed search for NCT06932211
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Gingival Inflammation
Currently open trials in the same condition.
- NCT07104019 — Biofiller and Gingival Phenotype Thickening · NA · recruiting
- NCT07100574 — Bacteria in Dental Plaque and Atheroma Plaque · recruiting
- NCT06752291 — EFFECTIVENESS of WATER FLOSS in PLAQUE REMOVAL and PREVENTION of WHITE SPOT LESIONS in ORTHODONTIC PATIENTS: a RANDOMISE · NA · active not recruiting
Other Unilever R&D trials
Trials by the same sponsor.
- NCT06640244 — The Effect of Cosmetic Face Care Products on Facial Skin Tone and Spot Brightening · NA · completed
- NCT06413810 — The Effects of a Food Ingredient on Self-reported Stress · NA · completed
- NCT05013801 — A Clinical Study to Evaluate the Effect of Facial Serum Q69 in Moderating the Appearance of Mild to Moderate Melasma · NA · completed
- NCT04155658 — Evaluation of Efficacy of Sodium Monofluorophosphate (SMPF) Toothpastes on Enamel Lesion Remineralisation · NA · completed
- NCT03953391 — The Effect of Tea Breaks on Cerebrovascular Perfusion During Desk Work · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06932211 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Unilever R&D
- Last refreshed: 17 April 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06932211.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing