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NCT06930430
IL-1β and S1P Levels After Periodontal Therapy: A Split-Mouth Study
NA trial testing Non-Surgical Periodontal Therapy (NSPT) in Sphingosine 1-phosphate in 17 participants. Completed in 10 September 2024.
18 April 2024
Quick facts
| Lead sponsor | Ondokuz Mayıs University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 17 |
| Start date | 15 May 2023 |
| Primary completion | 18 April 2024 |
| Estimated completion | 10 September 2024 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- Non-Surgical Periodontal Therapy (NSPT)
Conditions studied
- Sphingosine 1-phosphate — all drugs for Sphingosine 1-phosphate →
- Interleukin 1-beta — all drugs for Interleukin 1-beta →
- Gingival Crevicular Fluid — all drugs for Gingival Crevicular Fluid →
- Non-surgical Periodontal Therapy — all drugs for Non-surgical Periodontal Therapy →
Sponsor
Ondokuz Mayıs University
Who can join
Adults 45 to 60, any sex, with Sphingosine 1-phosphate or Interleukin 1-beta. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This randomized split-mouth clinical trial aimed to evaluate the changes in interleukin-1 beta (IL-1β) and sphingosine-1-phosphate (S1P) levels in gingival crevicular fluid (GCF) following non-surgical periodontal therapy (NSPT) in patients with stage III periodontitis. A total of 17 systemically healthy, non-smoking individuals were included. For each patient, three diseased and three healthy periodontal sites were selected, totaling 51 diseased and 51 healthy sites for biochemical and clinical evaluation. GCF samples and clinical periodontal parameters were collected at baseline, one month, and three months after NSPT. The levels of IL-1β and S1P were quantified using enzyme-linked immunosorbent assay (ELISA). The study also investigated the correlation between biomarker levels and clinical indicators of periodontal disease severity, such as probing depth and clinical attachment level.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT06930430
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06930430 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Ondokuz Mayıs University
- Last refreshed: 16 April 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06930430.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing