Association of the TNFAIP3 Genomic Locus With Immune-mediated TTP (A20iTTP)

NCT06928233 NA RECRUITING

This study aims to investigate whether genetic variation in the TNFAIP3 locus is associated with immune-mediated thrombotic thrombocytopenic purpura (iTTP), and whether such association is mediated by decreased expression of A20 (TNFAIP3). The study includes a case-control design to assess genotype-expression association and a cohort study to evaluate clinical outcomes such as disease relapse.

Details

Lead sponsor	Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Phase	NA
Status	RECRUITING
Enrolment	400
Start date	2025-04-07
Completion	2026-04

Conditions

• Thrombotic Thrombocytopenic Purpura, Acquired

Interventions

• blood sampling

Primary outcomes

• Allele frequency of TNFAIP3 variants in cases vs controls — Baseline

Countries

Italy