Who is sponsoring RAPID?

RAPID is sponsored by University of Hamburg-Eppendorf.

What condition does RAPID study?

RAPID studies Intraoperative Bradycardia.

What drugs are being tested in RAPID?

Interventions: Giving atropine at heart rates below 60 beats per minute, Giving atropine at heart rates below 30 beats per minute.

Last reviewed 2026-04-27 · How we verify

Treating Intraoperative Bradycardia in Non-cardiac Surgery Patients With Atropine at Heart Rates Below 60 Versus 30 Beats Per Minute and Norepinephrine Requirements: the Randomized RAPID Trial

NCT06922097 NA COMPLETED

The RAPID trial is a randomized, single-center trial investigating whether giving atropine at heart rates below 60 beats per minute versus giving atropine only at heart rates below 30 beats per minute reduces the amount of norepinephrine needed to keep MAP above 65 mmHg in non-cardiac surgery patients with intraoperative bradycardia.

Details

Lead sponsor	University of Hamburg-Eppendorf
Phase	NA
Status	COMPLETED
Enrolment	186
Start date	2025-04-07
Completion	2025-12-16

Conditions

Intraoperative Bradycardia

Interventions

Giving atropine at heart rates below 60 beats per minute
Giving atropine at heart rates below 30 beats per minute

Primary outcomes

Average norepinephrine infusion rate — Perioperative
Average norepinephrine infusion rate in μg per kg actual body weight per minute (μg kg-1 min-1) needed to keep MAP above 65 mmHg from anesthetic induction until the end of surgery (continuous outcome)

Countries

Germany