The Investigators Are Comparing Lidocaine and Papaverine Nerve Blocks to Determine Which Improves Blood Flow Better, Making the "Phoenix Sign" Clearer on Imaging. This Helps Accurately Diagnose Nerve Compression, Improving Patient Care

NCT06919289 NA COMPLETED

This pilot study aims to investigate the effects of nerve blocks in patients with diabetic peripheral neuropathy through a double-blinded, randomized trial involving 4 patients. Each participant will receive bilateral peripheral nerve blocks using either lidocaine or papaverine. Following randomization, each patient will receive one medication in one leg and the alternate medication in the contralateral leg. Researchers will measure parameters including motor strength, sensory function (two-point discrimination), arterial blood flow via Doppler ultrasound, and microvascular perfusion using near-infrared spectroscopy both prior to and following nerve block administration. This research seeks to explore potential diagnostic and therapeutic applications for peripheral nerve entrapment, a common yet challenging clinical condition.

Details

Lead sponsor	US Neuropathy Centers
Phase	NA
Status	COMPLETED
Enrolment	4
Start date	Thu Mar 07 2024 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Mon Jul 01 2024 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

• Drop Foot

Interventions

• Infiltration of papaverine
• Lidocaine infiltration

Countries

United States