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NCT06918145: LVA; AD
Clinical Study on Lymphaticovenous Anastomosis（LVA） for the Treatment of Alzheimer's Disease（AD）
NA trial testing Lymphaticovenous Anastomosis in Alzheimer&Amp;#39;s Disease (AD) in 80 participants. Enrolling by invitation.
1 March 2030
Quick facts
| Lead sponsor | Peking University Third Hospital |
|---|---|
| Phase | NA |
| Status | ENROLLING BY INVITATION |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 80 |
| Start date | 2 April 2025 |
| Primary completion | 1 March 2030 |
| Estimated completion | 1 March 2030 |
| Sites | 1 location across China |
Drugs / interventions tested
- Lymphaticovenous Anastomosis
Conditions studied
- Alzheimer&Amp;#39;s Disease (AD) — all drugs for Alzheimer&Amp;#39;s Disease (AD) →
Sponsor
Peking University Third Hospital
Who can join
Adults 50 to 85, any sex, with Alzheimer&Amp;#39;s Disease (AD). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this clinical trial is to explore the safety and efficacy of Lymphaticovenous Anastomosis (LVA) for the Treatment of Alzheimer's Disease (AD). The main questions it aims to answer are: 1. After LVA surgery treatment, do patients with AD show improvement in dementia, cognitive impairment, neurobehavioral symptoms? 2. What are the complications associated with LVA treatment for AD, including perioperative complications and long-term complications? 3. What is the mechanism of LVA treatment for AD patients, and what changes occur in AD-related biomarkers (Aβ42、 Aβ40、Aβ42/40、pTau217、pTau181) before and after surgery?
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Brain lymphatic drainage pathways, deep cervical lymphatic surgery, and current insights: A systematic review.
Lahmar T, Thuau F, Pinard G, Boutoleau-Bretonniere C, et al · · 2026 · cited 2× · PMID 40877101 · DOI 10.1016/j.tjpad.2025.100335
Verify or expand the search:
- PubMed search for NCT06918145
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Lymphaticovenous Anastomosis
Trials testing the same drug.
- NCT06706947 — Exploration of the Efficacy and Mechanisms of Lymphaticovenous Anastomosis in the Treatment of Alzheimer's Disease · NA · not yet recruiting
Other Peking University Third Hospital trials
Trials by the same sponsor.
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- NCT07470255 — Detection of Diabetic Foot Skin Damage Using Plantar Mechanical Parameters · not yet recruiting
- NCT07453381 — Multisensor Wireless Pressure Microcatheter For Microvascular Function Assessment In ANOCA/INOCA Patients: A Prospective · not yet recruiting
- NCT07452354 — AI-Based Diabetic Foot Recurrence Cohort · not yet recruiting
- NCT07423819 — Sports Rehabilitation Therapy for Knee Joint Sports Injuries: A Case Study of Anterior Cruciate Ligament Injury and Pate · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06918145 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Peking University Third Hospital
- Last refreshed: 9 April 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06918145.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing