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NCT06915675
Human Placenta Extract Use in Socket Preservation
NA trial testing Placental Extract in Dental Extraction in 10 participants. Participants enrolled and being followed up; not accepting new ones.
11 February 2025
Quick facts
| Lead sponsor | Saint-Joseph University |
|---|---|
| Phase | NA |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 10 |
| Start date | 23 August 2024 |
| Primary completion | 11 February 2025 |
| Estimated completion | 10 April 2025 |
| Sites | 1 location across Lebanon |
Drugs / interventions tested
- Placental Extract — full drug profile →
- Allograft — full drug profile →
Conditions studied
- Dental Extraction — all drugs for Dental Extraction →
Sponsor
Saint-Joseph University
Who can join
Adults 20 to 60, any sex, with Dental Extraction. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This split-mouth pilot study evaluates the effectiveness of flowable decellularized Human Placental Connective Tissue Matrix (HPCTM) in alveolar ridge preservation following tooth extraction. Patients will receive HPCTM mixed with allograft particles in one extraction socket and allograft particles solely in the contralateral socket. The primary outcome is to assess dimensional changes in the alveolar ridge in terms of soft tissue shrinkage using a super-imposed intra-oral scans taken at baseline , day 10, 21 and 30 post-op and bone resorption rate by comparing pre-op and 4 months post-op cone beam computed tomography scans. Secondary outcomes include clinical soft tissue healing evaluation and commentary. The HPCTM used in this study is regulated by the US FDA under Section 361 of the Public Health Service Act (21 CFR Part 1271.10(a)).
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
The Use of Flowable Decellularized Human Placental Connective Tissue Matrix in Alveolar Ridge Preservation: A Split-Mouth Pilot Study.
Husseini B, Younes R, Ghosn N, Miller R, et al · · 2025 · PMID 41294526 · DOI 10.3390/dj13110545
Verify or expand the search:
- PubMed search for NCT06915675
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Placental Extract
Trials testing the same drug.
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- NCT06506539 — Placenta Extract Gel as a Periodontal Local Delivery Drug · Phase 2 · completed
Other Saint-Joseph University trials
Trials by the same sponsor.
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- NCT07517601 — Erbium-doped Yttrium Aluminum Garnet (Er:YAG) Laser vs Conventional Ceramic Bracket Debonding: A Split-Mouth Clinical Tr · NA · active not recruiting
- NCT07525128 — Lateral GBR Using Two Types of Membrane With a Combination of Allograft-xenograft · Phase 4 · active not recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06915675 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Saint-Joseph University
- Last refreshed: 11 April 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06915675.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing