Last reviewed · How we verify
NCT06914817
Brillouin Microscopy Used to Evaluate Corneal Mechanical Properties
NA trial testing Brillouin optical scanning system (Intelon Optics) (BOSS) in Map Dot Fingerprint Dystrophy in 100 participants. Not yet recruiting.
1 October 2025
Quick facts
| Lead sponsor | Vienna Institute for Research in Ocular Surgery |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | basic science |
| Enrollment | 100 |
| Start date | 1 April 2025 |
| Primary completion | 1 October 2025 |
| Estimated completion | 1 October 2025 |
| Sites | 1 location across Austria |
Drugs / interventions tested
- Brillouin optical scanning system (Intelon Optics) (BOSS)
Conditions studied
- Map Dot Fingerprint Dystrophy — all drugs for Map Dot Fingerprint Dystrophy →
- Post-penetrating Keratoplasty — all drugs for Post-penetrating Keratoplasty →
- Post-Descemet Membrane Endothelial Keratoplasty — all drugs for Post-Descemet Membrane Endothelial Keratoplasty →
- Healthy Corneas — all drugs for Healthy Corneas →
Sponsor
Vienna Institute for Research in Ocular Surgery
Who can join
18 and older, any sex, with Map Dot Fingerprint Dystrophy or Post-penetrating Keratoplasty. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study aims to explore the mechanical properties of the cornea using a non-invasive imaging technique called Brillouin microscopy. This innovative method measures corneal elasticity by detecting small shifts in light frequency, which occur due to interactions with acoustic waves in the tissue. These measurements can provide insights into how corneal stiffness is altered in various eye diseases or after surgery. The study includes 100 participants, divided into different groups: patients with Fuchs' Endothelial Dystrophy (FED), Map Dot Fingerprint Dystrophy (MDFD), and those who have undergone corneal surgeries such as Penetrating Keratoplasty (PKP), Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK), and Descemet Membrane Endothelial Keratoplasty (DMEK). Healthy individuals will also be studied as a control group. Participants will first receive a standard eye exam, including a slit-lamp examination. Then, Brillouin microscopy will be used to measure the cornea's mechanical stiffness. Additional tests include optical coherence tomography (OCT), corneal topography and tomography, pachymetry (measuring corneal thickness), endothelial cell count, and intraocular pressure (IOP) measurement. The purpose of this study is to better understand how diseases and surgeries affect corneal biomechanics. The researchers will also examine how well the Brillouin measurements match with findings from other clinical imaging tests. The results may help improve diagnosis and treatment options for corneal disorders.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06914817
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other Vienna Institute for Research in Ocular Surgery trials
Trials by the same sponsor.
- NCT07262021 — Visual Function of Enhanced Monofocal Intraocular Lenses · NA · not yet recruiting
- NCT07297849 — Eyelid Closure in Keratometry · NA · recruiting
- NCT07390253 — Switch From 2mg Aflibercept to 8mg Aflibercept in Patients With Neovascular Age-related Macular Degeneration · active not recruiting
- NCT06607848 — Comparison of Two Non- Diffractive Extended Depth of Focus Intraocular Lenses · NA · recruiting
- NCT06358664 — Caffeine and Cataract After Pars Plana Vitrectomy · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06914817 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Vienna Institute for Research in Ocular Surgery
- Last refreshed: 6 April 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06914817.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing