NCT06908408: BE-Platelet

Correlation Between Base Excess in Patients Upon Admission to the ICU and Platelet Count Trend in the Following Days

Completed Last updated 3 April 2025

What this trial tests

trial testing Corrrelation between metabolic acidosis severity in patients on admission to the ICU and platelet count trend in 2 days following admission was investigated in Platelet Count Decline in Critically Ill in 484 participants. Completed in 14 February 2024.

Timeline

11 January 2024

Primary endpoint
11 February 2024

14 February 2024

Quick facts

Lead sponsor	University Medical Centre Ljubljana
Status	Completed
Study type	OBSERVATIONAL
Enrollment	484
Start date	11 January 2024
Primary completion	11 February 2024
Estimated completion	14 February 2024
Sites	1 location across Slovenia

Drugs / interventions tested

• Corrrelation between metabolic acidosis severity in patients on admission to the ICU and platelet count trend in 2 days following admission was investigated

Conditions studied

• Platelet Count Decline in Critically Ill — all drugs for Platelet Count Decline in Critically Ill →
• Metabolic Acidosis — all drugs for Metabolic Acidosis →
• Metabolic Acidosis Severity — all drugs for Metabolic Acidosis Severity →
• Platelet Count Decline in ICU Patients — all drugs for Platelet Count Decline in ICU Patients →

Sponsor

University Medical Centre Ljubljana

Who can join

14 and older, any sex, with Platelet Count Decline in Critically Ill or Metabolic Acidosis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Several studies have revealed that a relative platelet count decline in patients after their admission to the intensive care unit (ICU) is a very reliable marker of the severity of their sickness. ICU patients with a greater platelet count decline after their admission to the ICU have generally worse outcome. Investigators assume that a quick appearance of a deep metabolic acidosis, which commonly occurs in critically ill, has an important role in pathogenesis of relative platelet count decline. To evaluate this, correlation of metabolic acidosis severity in participants upon admission to the ICU with platelet count decline in 2 days, following admission, was investigated with a retrospective observational study, analysing all participants, admitted to the ICU in one year period (in 2020).

As a measurement of metabolic acidosis severity, investigators took base excess (BE) value (expressed in mmol/L) from arterial blood gas analysis with lowest pH in participants in around admission time (in a period from 24 hours before to 24 hours after their admission to the ICU). To calculate relative platelet count decline in 2 days after admission to the ICU, investigators took platelet count on admission to the ICU (P0) and lowest platelet count on day 2 after the patient's admission (P2). Following formula was used to calculate relative platelet count decline in 2 days after ICU admission (delta P): delta P = (P2-P0)/P0 x 100 (expressed in %). More negative values of delta P represent larger relative platelet count decline.

The main interest of the study was if BE value correlates with delta P. Investigators assumed that participants with a more severe metabolic acidosis upon admission to the ICU (represented with more negative BE value) would tend to have a larger relative platelet count decline in 2 days, following admission to the ICU (represented with more negative value of delta P).

Pearson correlation was used to evaluate correlation between BE and delta P.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.