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NCT06901323
Effect of L-carnitine Supplementation on Phenylalanine and Brain-derived Neurotrophic Factor Levels in Infants and Children With Phenylketonuria
Phase 4 trial testing L-carnitine in Phenylketonuria in 176 participants. Participants enrolled and being followed up; not accepting new ones.
1 March 2026
Quick facts
| Lead sponsor | Mansoura University |
|---|---|
| Phase | Phase 4 |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | sequential |
| Masking | none |
| Primary purpose | supportive care |
| Enrollment | 176 |
| Start date | 1 February 2025 |
| Primary completion | 1 March 2026 |
| Estimated completion | 1 August 2026 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- L-carnitine — full drug profile →
Conditions studied
- Phenylketonuria — all drugs for Phenylketonuria →
Sponsor
Mansoura University
Who can join
Adults 1 Month to 18, any sex, with Phenylketonuria. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Effect of L-carnitine supplementation on phenylalanine and brain-derived neurotrophic factor levels in infants and children with phenylketonuria L-carnitine is mainly obtained from foods such as red meat and milk that are limited for PKU patients due to dietary protein restriction. So, L-carnitine deficiency has been described in phenylketonuric patients The aim of this study is to : 1. Compare level of Brain-derived neurotrophic factor in infants and children with phenylketonuria and healthy infants and children. 2. Compare level of phenylalanine and Brain-derived neurotrophic factor before and after L-carnitine supplementation in phenylketonuric patients. 3. Assess Intelligence quotient test before and after L-carnitine supplementation in phenylketonuric patients
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06901323
- Europe PMC full search
- ASCO Meeting Library
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Other recruiting trials for Phenylketonuria
Currently open trials in the same condition.
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06901323 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Mansoura University
- Last refreshed: 4 April 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06901323.
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