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NCT06894004
Mechanism of Ketogenic Diet-Induced Hypercholesterolemia
NA trial testing Ketogenic Diet in Hypercholesterolemia and Hyperlipidemia in 100 participants. Currently enrolling.
30 November 2030
Quick facts
| Lead sponsor | Washington University School of Medicine |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | none |
| Primary purpose | basic science |
| Enrollment | 100 |
| Start date | 24 February 2025 |
| Primary completion | 30 November 2030 |
| Estimated completion | 30 November 2030 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Ketogenic Diet — full drug profile →
- Control Diet
Conditions studied
- Hypercholesterolemia and Hyperlipidemia — all drugs for Hypercholesterolemia and Hyperlipidemia →
Sponsor
Washington University School of Medicine
Who can join
Adults 18 to 39, any sex, with Hypercholesterolemia and Hyperlipidemia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Very-low carbohydrate ketogenic diets can dramatically increase blood cholesterol levels, particularly in normal-weight people, for reasons that are not well understood. This study will enroll normal-weight adults, will identify "responders" who develop high cholesterol on a ketogenic diet, and will measure rates of production and removal of certain types of cholesterol-carrying particles called lipoproteins in responders. The results will clarify the mechanism by which a ketogenic diet can cause high cholesterol in certain susceptible people.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06894004
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Ketogenic Diet
Trials testing the same drug.
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- NCT06515912 — Ketogenic Diet in Healthy Adults With Differing BMI · NA · completed
- NCT06503809 — Efficacy and Safety of a Ketogenic Diet in Type 1 Diabetes · NA · recruiting
- NCT06325644 — Well-Formulated Ketogenic Diet Polycystic Kidney Disease · NA · recruiting
- NCT06715436 — Multiple Sclerosis and the Effects of Ketogenic Diet Therapy · NA · recruiting
Other Washington University School of Medicine trials
Trials by the same sponsor.
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- NCT07313592 — Whole Genome Sequencing (ChromoSeq®) for Acute Lymphoblastic Leukemia (ALL) Patients · not yet recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06894004 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Washington University School of Medicine
- Last refreshed: 23 March 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06894004.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing