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NCT06890052
Effects of Isolated Lumbar Extension Resistance Training Alone and in Combination with General Exercise and Manual Therapy
NA trial testing Targeted exercise program in Low Back Pain in 72 participants. Participants enrolled and being followed up; not accepting new ones.
24 December 2024
Quick facts
| Lead sponsor | University of Wuerzburg |
|---|---|
| Phase | NA |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 72 |
| Start date | 1 December 2021 |
| Primary completion | 24 December 2024 |
| Estimated completion | 24 June 2025 |
| Sites | 1 location across Germany |
Drugs / interventions tested
- Targeted exercise program
- Targeted exercise as part of an integrative therapy program
Conditions studied
- Low Back Pain — all drugs for Low Back Pain →
- Multifidus — all drugs for Multifidus →
- Exercise Therapy — all drugs for Exercise Therapy →
- Diagnostic Imaging — all drugs for Diagnostic Imaging →
Sponsor
University of Wuerzburg
Who can join
Adults 18 to 65, any sex, with Low Back Pain or Multifidus. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study examines effects of machine-based isolated lumbar extension resistance exercise (ILEX) on paraspinal muscle morphology and function, as well as pain intensity, disability and quality of life in patients with chronic low back pain and radiculopathy related to specific spinal disorders. Current guidelines emphasize the necessity of treating chronic low back pain with integrative, holistic approaches due to its multidimensional nature. At the same time, an increasing number of studies highlight the importance of restoring lumbar muscle function and morphology through targeted training. Regarding ILEX, existing studies already support its clinical value, however, the optimal integration of ILEX with other therapeutic modalities remains unclear. Two groups will be enrolled in an ILEX protocol (16 weeks, 25 sessions), while one of the groups will additionally participate in general exercise and manual therapy. After completion of the main program, participants will be given different options to continue the exercise therapy with a reduced frequency (e.g., once per month). After six months, a follow-up assessment will be conducted with all participants to analyze long-term efficacy.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Isolated lumbar extension exercise alone or in a multimodal program for low back pain and radiculopathy: a non-randomized controlled trial.
Domokos B, Domokos J, Andersson G, Mannel S, et al · · 2025 · PMID 41131158 · DOI 10.1038/s41598-025-22452-x
Verify or expand the search:
- PubMed search for NCT06890052
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06890052 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Wuerzburg
- Last refreshed: 21 March 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06890052.
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