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LEAN Mass Preservation With Resistance Exercise and Protein During Semaglutide/Tirzepatide Therapy (LEAN-PREP)
The aim of the current study is to determine whether resistance exercise and/or protein intake can preserve lean mass and improve physical function in patients with obesity initiating semaglutide/tirzepatide therapy. To achieve this aim the study will have the following objectives. In people with obesity initiating semaglutide/tirzepatide therapy 1. Form a PPI group to refine the study protocol and establish study materials, 2. Quantify the effects of a pragmatic resistance exercise intervention and/or increasing protein intake on lean mass and physical function during semaglutide/tirzepatide induced weight loss, 3. Establish whether the resistance exercise intervention and/or increasing protein intake has concomitant benefits on glycaemic control, lipids, liver function, quality of life, physical activity and sleep during semaglutide/tirzepatide induced weight loss. The participants will: Begin their weight loss medication, starting at a low dose and then increasing the dose to maximize weight loss. They will be randomly assigned by a computer to ONE of the following groups and will be followed up to 6-months: * Control group * Protein intake group * Muscle strengthening exercise group * Muscle strengthening exercise AND protein intake group.
Details
| Lead sponsor | Dasman Diabetes Institute |
|---|---|
| Phase | NA |
| Status | RECRUITING |
| Enrolment | 232 |
| Start date | Thu Aug 07 2025 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Mon Dec 31 2029 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Obesity
Interventions
- Resistance exercise
- Protein Intake
Countries
Kuwait